Ikeda H
Dept. of Radiation Oncology, Osaka Univ. Med. School.
Gan No Rinsho. 1990 Oct;36(13):2244-7.
Clinical results and experiences with the combination of radiotherapy and radiosensitizing agents to the head and neck cancers were reported. Each of chemotherapeutic agents, 5-FU, Bleomycin, Peplomycin, Adriamycin, and Cisplatin had a radiosensitizing effect, and was expected to affect additively to radiotherapy, which led to the improvement of local control rate, reduction of dose of external radiotherapy by 10-20 Gy/1-2 weeks or more, or reduction or dispersion of treatment-related injury. Especially in the management of head and neck cancers, those merits also led to the preservation of function or cosmesis and the saving from the radical surgery in a substantial amount of cases. It was also stressed that the judgment of whether or not the salvage surgery/brachytherapy is necessary must be critically done for each case during the RT course.
报告了头颈部癌放疗与放射增敏剂联合应用的临床结果和经验。每种化疗药物，如5-氟尿嘧啶、博来霉素、培洛霉素、阿霉素和顺铂都具有放射增敏作用，并预期能与放疗产生相加效应，从而提高局部控制率，使外照射剂量在1 - 2周内减少10 - 20 Gy或更多，或减少或分散治疗相关损伤。特别是在头颈部癌的治疗中，这些优点还能在大量病例中保留功能或美容效果，并避免根治性手术。还强调在放疗过程中，必须针对每个病例严格判断是否需要挽救性手术/近距离放疗。
