Santoro M, Rosati R, Grieco M, Berlingieri M T, D'Amato G L, de Franciscis V, Fusco A
Centro di Endocrinologia ed Oncologia Sperimentale del CNR, II Facoltà di Medicina e Chirurgia, Università di Napoli, Italy.
Oncogene. 1990 Oct;5(10):1595-8.
We have recently reported the identification of a new oncogene, named PTC, frequently activated in human thyroid papillary carcinomas. This gene is a novel rearranged form of the ret proto-oncogene and we have shown that this rearrangement occurred in vivo as a tumor-specific somatic event. In an effort to further examine the role of this oncogene in human malignancies, we have investigated the expression of the ret oncogene in a number of human tumors. We consistently detected expression of normal-sized transcripts of the ret proto-oncogene in human pheochromocytomas and in human medullary thyroid carcinomas (MTC), both of familial and sporadic type. Moreover, we showed that ret mRNA levels were increased following (Bu)2cAMP-induced differentiation of a human MTC cell line (TT). Since the ret gene has been mapped on chromosome 10, close to the gene which predisposes patients to the MEN2A syndrome, we suggest that this region of chromosome 10 might be involved in the proliferative and differentiative patterns of these neuroectodermal tissues.
我们最近报告了一种新的癌基因的鉴定，该基因名为PTC，在人类甲状腺乳头状癌中经常被激活。这个基因是原癌基因ret的一种新的重排形式，并且我们已经表明这种重排作为一种肿瘤特异性体细胞事件在体内发生。为了进一步研究这种癌基因在人类恶性肿瘤中的作用，我们研究了ret原癌基因在多种人类肿瘤中的表达。我们在人类嗜铬细胞瘤和家族性及散发性的人类甲状腺髓样癌（MTC）中持续检测到ret原癌基因正常大小转录本的表达。此外，我们表明，在（Bu）2cAMP诱导的人类MTC细胞系（TT）分化后，ret mRNA水平升高。由于ret基因已定位于10号染色体，靠近使患者易患MEN2A综合征的基因，我们认为10号染色体的这个区域可能参与了这些神经外胚层组织的增殖和分化模式。
