Gearry Richard B, Richardson Ann, Frampton Christopher M A, Collett Judith A, Burt Michael J, Chapman Bruce A, Barclay Murray L
Department of Medicine, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand.
Inflamm Bowel Dis. 2006 Oct;12(10):936-43. doi: 10.1097/01.mib.0000231572.88806.b9.
Inflammatory bowel disease (IBD) has increased exponentially in industrialized nations over the last 50 years. Previous New Zealand studies have shown that IBD is less common than in other countries; however, clinical observations suggested a high incidence and prevalence of IBD in Canterbury, particularly Crohn's disease (CD).
This study aimed to determine the descriptive epidemiology of IBD in Canterbury.
Canterbury IBD patients, recruited using multiple strategies, gave informed consent, permission for clinical record review, completed a questionnaire, and were bled for DNA extraction as part of the Canterbury IBD Project. Cases were confirmed using standard criteria, and completeness of recruitment was validated using capture-recapture methods. Demographic and phenotypic data were extracted from case notes. One thousand four hundred twenty patients (715 CD, 668 ulcerative colitis [UC]) were recruited (> 91% of Canterbury IBD patients).
In 2004, age-standardized (World Health Organization World Standard Population) IBD, CD, and UC incidence rates were 25.2, 16.5, and 7.6/100,000/year, respectively. The IBD, CD, and UC point prevalences on 1 June, 2005 were 308.3, 155.2, and 145.0/100,000, respectively. CD patients were more likely than UC patients to be female (61.4% vs. 47.1%) and to be younger (median age, 39.9 years vs. 43.7 years). The percent of IBD patients who were white was 97.5%.
IBD is at least as common in Canterbury as in other western regions. CD incidence and prevalence are amongst the highest ever reported and are higher than for UC. IBD population characteristics are otherwise similar to other countries. The Canterbury IBD Project will be a valuable tool for future population-based IBD epidemiology and genetics research.
在过去50年中，炎症性肠病（IBD）在工业化国家呈指数级增长。此前新西兰的研究表明，IBD的发病率低于其他国家；然而，临床观察显示，坎特伯雷地区IBD的发病率和患病率较高，尤其是克罗恩病（CD）。
本研究旨在确定坎特伯雷地区IBD的描述性流行病学特征。
作为坎特伯雷IBD项目的一部分，通过多种策略招募该地区的IBD患者，患者签署知情同意书并允许查阅临床记录，完成一份问卷，并采集血液用于DNA提取。病例按照标准标准进行确诊，使用捕获-再捕获方法验证招募的完整性。从病例记录中提取人口统计学和表型数据。共招募了1420名患者（715例CD，668例溃疡性结肠炎[UC]）（超过坎特伯雷地区IBD患者的91%）。
2004年，年龄标准化（世界卫生组织世界标准人口）的IBD、CD和UC发病率分别为每年25.2/10万、16.5/10万和7.6/10万。2005年6月1日，IBD、CD和UC的时点患病率分别为308.3/10万、155.2/10万和145.0/10万。CD患者比UC患者更可能为女性（61.4%对47.1%）且更年轻（中位年龄，39.9岁对43.7岁）。IBD患者中白人的比例为97.5%。
IBD在坎特伯雷地区至少与其他西部地区一样常见。CD的发病率和患病率是有记录以来最高的，且高于UC。IBD的人群特征在其他方面与其他国家相似。坎特伯雷IBD项目将成为未来基于人群的IBD流行病学和遗传学研究的宝贵工具。
