Su Heidi Y, Gupta Vikesh, Day Andrew S, Gearry Richard B
*Department of Gastroenterology, Christchurch Hospital, Christchurch, New Zealand; †Department of Medicine, University of Otago, Christchurch, New Zealand; and ‡Department of Paediatrics, Christchurch Hospital, Christchurch, New Zealand; Department of Paediatrics, University of Otago, Christchurch, New Zealand.
Inflamm Bowel Dis. 2016 Sep;22(9):2238-44. doi: 10.1097/MIB.0000000000000829.
A population-based study of inflammatory bowel disease (IBD) in the Canterbury province of New Zealand demonstrated an incidence of Crohn's disease (CD) of 16.5 per 100,000 population in 2004, along with a high rate of IBD overall. At the time, this was one of the highest rates of CD in the world. The current study aimed to ascertain the incidence of IBD in the same area 10 years later.
All patients diagnosed with IBD in 2014 within the Canterbury region were identified and characterized. Diagnosis and disease classification were ascertained using standard accepted criteria. Projected population data for age and gender were used to calculate incidence rates for IBD overall and for CD, ulcerative colitis (UC), and inflammatory bowel disease-unclassified (IBDU).
During the 2014 years, 205 patients were diagnosed with IBD in Canterbury. This group comprised 134 patients with CD, 69 with UC, and 2 with IBDU. The age-standardized incidence of IBD, CD, UC, and IBDU was 39.5, 26.4, 12.6, and 0.17 per 100,000, respectively. Disease location of CD patients was evenly distributed (ileal 29%, colonic 35%, and ileocolonic 32%). Similarly, patients with UC had even distribution of proctitis, left-sided, and extensive disease.
This study demonstrates a substantial increase in the incidence of IBD in this geographically well-defined area. Overall, incidence rates were 1.6-fold greater than when assessed 10 years earlier. The reasons contributing to these continued increases remain unclear. However, further increases in rates of IBD indicate growing health system demands in the future.
一项针对新西兰坎特伯雷地区炎性肠病（IBD）的基于人群的研究表明，2004年克罗恩病（CD）的发病率为每10万人中有16.5例，同时IBD总体发病率较高。当时，这是世界上CD发病率最高的地区之一。当前研究旨在确定10年后该地区IBD的发病率。
识别并描述2014年在坎特伯雷地区被诊断为IBD的所有患者。使用公认的标准确定诊断和疾病分类。采用年龄和性别的预计人口数据来计算IBD总体以及CD、溃疡性结肠炎（UC）和未分类炎性肠病（IBDU）的发病率。
在2014年期间，坎特伯雷地区有205例患者被诊断为IBD。该组包括134例CD患者、69例UC患者和2例IBDU患者。IBD、CD、UC和IBDU的年龄标准化发病率分别为每10万人39.5例、26.4例、12.6例和0.17例。CD患者的疾病部位分布均匀（回肠29%、结肠35%、回结肠32%）。同样，UC患者的直肠炎、左侧病变和广泛性病变分布也均匀。
本研究表明在这个地理区域明确的地区，IBD发病率大幅上升。总体而言，发病率比10年前评估时高出1.6倍。导致这些持续上升的原因尚不清楚。然而，IBD发病率的进一步上升表明未来卫生系统需求将不断增加。
