Siekmeier R, Steffen C, März W
Bundesinstitut für Arzneimittel und Medizinprodukte (BfArM), Kurt-Georg-Kiesinger-Allee 3, 53175 Bonn, BRD.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2006 Oct;49(10):1034-49. doi: 10.1007/s00103-006-0048-y.
In vitro studies have shown that antioxidants (e. g. beta-carotene, vitamin C and vitamin E) can interfere with some pathomechanisms of atherosclerosis and therefore might have a protective effect. From the investigated antioxidants vitamin E showed the best effect. Some animal and epidemiological studies confirmed such a protective effect in vivo especially after administration of high doses of vitamin E. However, most of the placebo-controlled studies for primary or secondary prevention failed to show a protective effect even after administration of high doses. In addition, other studies demonstrated a risk for adverse effects due to antioxidant supplementation (beta-carotene and vitamin E). Our review summarises the principle of antioxidant supplementation and a number of relevant epidemiological and clinical studies for prevention of atherosclerosis. The obtained results suggest that supplementation of antioxidants cannot be recommended for the normal population.
体外研究表明，抗氧化剂（如β-胡萝卜素、维生素C和维生素E）可干扰动脉粥样硬化的某些发病机制，因此可能具有保护作用。在所研究的抗氧化剂中，维生素E显示出最佳效果。一些动物和流行病学研究证实了这种体内保护作用，尤其是在给予高剂量维生素E之后。然而，大多数用于一级或二级预防的安慰剂对照研究即使在给予高剂量后也未能显示出保护作用。此外，其他研究表明抗氧化剂补充剂（β-胡萝卜素和维生素E）存在不良反应风险。我们的综述总结了抗氧化剂补充的原理以及一些预防动脉粥样硬化的相关流行病学和临床研究。所得结果表明，不建议正常人群补充抗氧化剂。
