Jovanovic Tanja, Norrholm Seth D, Keyes Megan, Fiallos Ana, Jovanovic Sasa, Myers Karyn M, Davis Michael, Duncan Erica J
Mental Health Service/116A, Atlanta Veterans Affairs Medical Center, Decatur, GA 30033, USA.
Behav Neurosci. 2006 Oct;120(5):995-1004. doi: 10.1037/0735-7044.120.5.995.
Fear-potentiated startle is defined as an increase in the magnitude of the startle reflex in the presence of a stimulus that was previously paired with an aversive event. It has been proposed that a subject's awareness of the contingencies in the experiment may affect fear-potentiated startle. The authors adapted a conditional discrimination procedure (AX+/BX-), previously validated in animals, to a human fear-potentiated startle paradigm in 50 healthy volunteers. This paradigm allows for an assessment of fear-potentiated startle during threat conditions as well as inhibition of fear-potentiated startle during safety conditions. A response keypad was used to assess contingency awareness on a trial-by-trial basis. Both aware and unaware subjects showed fear-potentiated startle. However, awareness was related to stimulus discrimination and fear inhibition.
恐惧增强型惊跳反应被定义为在先前与厌恶事件配对的刺激出现时，惊跳反射幅度的增加。有人提出，受试者对实验中意外情况的意识可能会影响恐惧增强型惊跳反应。作者将一种先前在动物身上验证过的条件辨别程序（AX+/BX-）应用于50名健康志愿者的人类恐惧增强型惊跳范式。这种范式允许在威胁条件下评估恐惧增强型惊跳反应，以及在安全条件下评估恐惧增强型惊跳反应的抑制情况。使用响应键盘逐次试验地评估意外情况意识。有意识和无意识的受试者都表现出恐惧增强型惊跳反应。然而，意识与刺激辨别和恐惧抑制有关。
