Spatial location is critical for conditioning place preference with visual but not tactile stimuli.

The roles of visual, tactile, and spatial location cues were studied in 6 conditioned place preference (CPP) experiments with ethanol (2 g/kg) in mice (of the DBA/2J strain). Visual cues were effective conditioned stimuli (CSs) when consistently presented in the same spatial location, but not when the same cue was presented in two different locations during training. In contrast, tactile CSs were effective regardless of spatial location during training. Moreover, spatial location controlled CPP expression when visual cues were used but not when tactile cues were used. However, spatial location per se was not an effective CS. These studies suggest that CPP conditioned to tactile cues is mediated by brain systems different from those mediating CPP conditioned to visual-spatial cues.