Woods Amanda M, Bouton Mark E
Department of Psychology, University of Vermont, Burlington, VT 05405, USA.
Behav Neurosci. 2006 Oct;120(5):1159-62. doi: 10.1037/0735-7044.120.5.1159.
The effect of D-cycloserine (DCS), an NMDA partial agonist, on extinction of fear was investigated in rats using the conditioned emotional response preparation. Fear extinction was facilitated when the first 4 trials occurred with a 30-mg/kg dose of DCS. However, extinguished fear was "renewed" regardless of the drug treatment when the rats were returned to the context in which fear had been conditioned. Additional results suggest that DCS's facilitation of extinction is a small but meaningful effect in the current method. The results suggest caution regarding the use of DCS as an adjunct to extinction: Although the drug may modestly facilitate extinction learning, it does not necessarily destroy the potential for relapse. Behavioral mechanisms are discussed.
使用条件性情绪反应实验，在大鼠中研究了N-甲基-D-天冬氨酸（NMDA）部分激动剂D-环丝氨酸（DCS）对恐惧消退的影响。当最初4次试验使用30mg/kg剂量的DCS时，恐惧消退得到促进。然而，当大鼠回到曾形成恐惧条件的环境中时，无论药物治疗情况如何，消退的恐惧都会“复发”。其他结果表明，在当前方法中，DCS对消退的促进作用虽小但有意义。结果提示在将DCS用作消退辅助手段时需谨慎：尽管该药物可能适度促进消退学习，但不一定能消除复发的可能性。文中还讨论了行为机制。
