Wathen-Grady H G, Britt L E, Strockbine N A, Wachsmuth I K
World Health Organization International Collaborating Center for Shigella and Enteric Diseases, Centers for Disease Control, Atlanta, Georgia 30333.
J Clin Microbiol. 1990 Nov;28(11):2580-4. doi: 10.1128/jcm.28.11.2580-2584.1990.
We conducted serologic and biochemical studies on strains of three provisional Shigella serotypes. Included were 19 strains of serotype 3873-50 from three countries (1 from Mexico, 1 from Netherlands Antilles, and 17 from the United States), 13 strains of serotype 3341-55 from three countries (1 from Canada, 1 from Bulgaria, and 11 from the United States), and 19 strains of serotype 19809-73 from two countries (16 from Israel and 3 from the United States). Reactions of these strains with homologous and heterologous Shigella antisera showed that serotypes 3873-50 and 19809-73 were unique. Strains of serotype 3341-55 shared an identical antigen with Shigella boydii 18; however, they were distinguished from S. boydii 18 biochemically and with absorbed sera. Strains of the three serotypes were biochemically most similar to Shigella dysenteriae. Like other shigellae, strains from each serotype were invasive in the Serény assay. Although biochemically similar to S. dysenteriae, none of the provisional serotypes produced Shiga toxin or the biologically related toxin, Shiga-like toxin II, produced by some strains of Escherichia coli. On the basis of these results and other published findings, we support earlier proposals to add the three provisional serotypes 3873-50, 3341-55, and 19809-73 to the Shigella schema and will include them as S. dysenteriae 11, 12, and 13, respectively.
我们对三种暂定志贺氏菌血清型的菌株进行了血清学和生化研究。其中包括来自三个国家的19株血清型3873 - 50菌株（1株来自墨西哥，1株来自荷属安的列斯群岛，17株来自美国），来自三个国家的13株血清型3341 - 55菌株（1株来自加拿大，1株来自保加利亚，11株来自美国），以及来自两个国家的19株血清型19809 - 73菌株（16株来自以色列，3株来自美国）。这些菌株与同源和异源志贺氏菌抗血清的反应表明，血清型3873 - 50和19809 - 73是独特的。血清型3341 - 55的菌株与鲍氏志贺氏菌18型具有相同的抗原；然而，它们在生化特性和吸收血清方面与鲍氏志贺氏菌18型有所区别。这三种血清型的菌株在生化特性上与痢疾志贺氏菌最为相似。与其他志贺氏菌一样，每种血清型的菌株在塞雷尼试验中具有侵袭性。尽管在生化特性上与痢疾志贺氏菌相似，但这些暂定血清型中没有一种产生志贺毒素或某些大肠杆菌菌株产生的生物学相关毒素——志贺样毒素II。基于这些结果和其他已发表的研究发现，我们支持早期的提议——将三种暂定血清型3873 - 50、3341 - 55和19809 - 73添加到志贺氏菌分类体系中，并将它们分别列为痢疾志贺氏菌11型、12型和13型。
