Kapural Leonardo, Narouze Samer N, Janicki Thomas I, Mekhail Nagy
Pain Management Department, The Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Pain Med. 2006 Sep-Oct;7(5):440-3. doi: 10.1111/j.1526-4637.2006.00165.x.
Recent studies have demonstrated significant involvement of dorsal column pathways in transmission of visceral pelvic pain. Spinal cord stimulation (SCS) suppresses visceral response to colon distension in an animal model and therefore may be an effective therapy for chronic pelvic pain of visceral origin. We are reporting on the value of neurostimulation for chronic visceral pelvic pain in six female patients with the diagnosis of long-standing pelvic pain (history of endometriosis, multiple surgical explorations, and dyspareunia).
Case-series report. All patients received repeated hypogastric blocks (in an average of 5.3 blocks) with a significant pain relief for a period ranging from 1 to 6 weeks. Three received neurolytic hypogastric block with the pain relief of 3, 8, and 12 months, respectively. Following psychological evaluation and clearance by our Multidisciplinary Committee on Implantable Devices, they all underwent SCS trial for 7-14 days. All patients received SCS systems with dual leads (Compact or Quad leads, Medtronic Inc., Minneapolis, MN, USA).
The average follow-up was 30.6 months. Median visual analog scale pain score decreased from 8 to 3. All patients had more than 50% of the pain relief. Pain Disability Index changed from an average of 57.7 +/- 12 to 19.5 +/- 7. Opiate use decreased from an average 22.5 mg to 6.6 mg of morphine sulfate milligram equivalents per day.
It appears that SCS may have a significant therapeutic potential for treatment of visceral pelvic pain.
近期研究表明,脊髓后索通路在盆腔内脏痛的传递中起重要作用。在动物模型中,脊髓刺激(SCS)可抑制对结肠扩张的内脏反应,因此可能是治疗内脏源性慢性盆腔痛的有效方法。我们报告了神经刺激对6例诊断为长期盆腔痛(有子宫内膜异位症病史、多次手术探查及性交困难)的女性慢性内脏盆腔痛患者的价值。
病例系列报告。所有患者均接受了反复的下腹神经阻滞(平均5.3次阻滞),疼痛显著缓解,持续时间为1至6周。3例患者接受了神经破坏性下腹神经阻滞,疼痛缓解时间分别为3个月、8个月和12个月。在经过心理评估并获得我们的植入式设备多学科委员会批准后,她们均接受了7至14天的SCS试验。所有患者均接受了带有双极导联的SCS系统(Compact或Quad导联,美敦力公司,美国明尼阿波利斯)。
平均随访30.6个月。视觉模拟评分法疼痛评分中位数从8分降至3分。所有患者的疼痛缓解均超过50%。疼痛残疾指数从平均57.7±12降至19.5±7。阿片类药物的使用量从平均每天22.5毫克吗啡硫酸毫克当量降至6.6毫克。
SCS似乎对内脏盆腔痛的治疗具有显著的治疗潜力。