Llorens J, Tusell J M, Suñol C, Rodríguez-Farré E
Department of Neurochemistry, Consejo Superior Investigaciones Científicas (CSIC), Barcelona, Spain.
Neurotoxicol Teratol. 1990 Nov-Dec;12(6):643-7. doi: 10.1016/0892-0362(90)90078-q.
The behavioral effects of an acute subconvulsant dose of the insecticide and ectoparasiticide gamma-hexachlorocyclohexane, lindane, were compared in the plus-maze ((+)-maze) animal model of anxiety to those elicited by the anxiogenic GABAA-antagonist pentylenetetrazole (PTZ) and the anxiolytic benzodiazepine diazepam. The effects of the coadministration of diazepam and lindane, and of diazepam and PTZ were also studied. The results from the analysis of the data with the multivariate statistical technique principal component analysis indicated that the effects of subconvulsant doses of lindane and PTZ on the behavior of rats in the (+)-maze are similar, and opposite to those elicited by diazepam, and that the administration of the convulsants would antagonize the effects of the benzodiazepine. The putative anxiogenic properties of the insecticide and the utility of the (+)-maze model in neurotoxicological research are discussed.
在焦虑的加迷宫（（+）-迷宫）动物模型中，将急性亚惊厥剂量的杀虫剂和杀外寄生虫剂γ-六氯环己烷（林丹）的行为效应与致焦虑的GABAA拮抗剂戊四氮（PTZ）和抗焦虑的苯二氮卓类地西泮所引发的效应进行了比较。还研究了地西泮与林丹以及地西泮与PTZ联合给药的效应。使用多元统计技术主成分分析对数据进行分析的结果表明，亚惊厥剂量的林丹和PTZ对大鼠在（+）-迷宫中行为的影响相似，且与地西泮所引发的效应相反，并且惊厥剂的给药会拮抗苯二氮卓类药物的效应。讨论了该杀虫剂假定的致焦虑特性以及（+）-迷宫模型在神经毒理学研究中的效用。
