Teixeira M Z
Department of Clinical Medicine, Faculty of Medicine, Universidade de São Paulo, São Paulo, Brazil.
Homeopathy. 2006 Oct;95(4):229-36. doi: 10.1016/j.homp.2006.06.004.
Samuel Hahnemann attributed fundamental importance to the principle of similitude, promoting it to a 'natural law'. Observing that enantiopathic or allopathic treatment produced enduring aggravation of the disease symptoms after a brief and transitory initial relief, he systematised homeopathic treatment, prescribing substances that provoke similar symptoms in healthy individual. Based on clinical and experimental observations, he anticipated the concept of homeostasis, dividing the effects of substances into: primary action of the medicine followed by secondary action or reaction of the organism. This reaction, known as the rebound effect or paradoxical action by modern pharmacology, used to awake the curative response of the body when the principle of similitude is applied, is responsible for several iatrogenic diseases when used on the basis of the principle of contraries. This study discusses the role of this paradoxical reaction of the organism in the fatal side effects of four important drugs, used according to the model of enantiopathic treatment of the symptoms. I present evidence relating to acetylsalicylic acid, rofecoxib, antidepressants and long-acting bronchodilators. The consequences of the allopathic treatment could be decreased if health professionals valued homeostasis, minimising the rebound effect of the organism by gradual suspension of palliative drugs.
塞缪尔·哈内曼认为相似性原则至关重要，并将其提升为一种“自然法则”。他观察到对抗疗法或顺势疗法在短暂的初始缓解后会导致疾病症状的持续加重，于是他将顺势疗法系统化，开出处方让健康个体产生类似症状的物质。基于临床和实验观察，他预见了体内平衡的概念，将物质的作用分为：药物的主要作用，随后是机体的次要作用或反应。这种反应，现代药理学称之为反弹效应或矛盾作用，在应用相似性原则时用于唤醒身体的治愈反应，但基于相反原则使用时会导致多种医源性疾病。本研究讨论了机体的这种矛盾反应在四种重要药物致命副作用中的作用，这四种药物是根据症状的对抗疗法模型使用的。我提供了有关乙酰水杨酸、罗非昔布、抗抑郁药和长效支气管扩张剂的证据。如果医疗专业人员重视体内平衡，通过逐渐停用缓解症状的药物来尽量减少机体的反弹效应，对抗疗法治疗的后果可能会降低。
