Teixeira Marcus Zulian
Department of Internal Medicine, Universidade de São Paulo, Brazil.
Homeopathy. 2010 Oct;99(4):255-62. doi: 10.1016/j.homp.2010.01.001.
Hahnemann considered the secondary action of medicines to be a law of nature and reviewed the conditions under which it occurs. It is closely related to the rebound effects observed with many modern drugs. I review the evidence of the rebound effect of statins that support the similitude principle. In view of their indications in primary and secondary prevention of cardiovascular diseases, statins are widely prescribed. Besides reducing cholesterol biosynthesis, they provide vasculoprotective effects (pleiotropic effects), including improvement of endothelial function, increased nitric oxide bioavailability, antioxidant properties, inhibition of inflammatory and thrombogenic responses, stabilisation of atherosclerotic plaques, and others. Recent studies suggest that suspension of statin treatment leads to a rebound imparing of vascular function, and increasing morbidity and mortality in patients with vascular diseases. Similarly to other classes of modern palliative drugs, this rebound effect is the same as a secondary action or vital reaction described by Samuel Hahnemann, and used in homeopathy in a therapeutic sense.
哈内曼认为药物的继发作用是一种自然规律，并审视了其发生的条件。这与许多现代药物所观察到的反跳效应密切相关。我回顾了支持相似性原则的他汀类药物反跳效应的证据。鉴于他汀类药物在心血管疾病一级和二级预防中的适应证，它们被广泛处方。除了降低胆固醇生物合成外，它们还具有血管保护作用（多效性作用），包括改善内皮功能、增加一氧化氮生物利用度、抗氧化特性、抑制炎症和血栓形成反应、稳定动脉粥样硬化斑块等。最近的研究表明，停用他汀类药物治疗会导致血管功能反跳受损，并增加血管疾病患者的发病率和死亡率。与其他类现代姑息性药物类似，这种反跳效应与塞缪尔·哈内曼所描述的继发作用或生命反应相同，并在顺势疗法中用于治疗目的。
