Llamas Bastien, Lau Catherine, Cupples William A, Rainville Marie-Line, Souzeau Emmanuelle, Deschepper Christian F
Experimental Cardiovascular Biology Research Unit, Institut de Recherches Cliniques de Montréal, Montréal, Quebec, Canada H2W 1R7.
Hypertension. 2006 Nov;48(5):921-6. doi: 10.1161/01.HYP.0000244758.50351.29. Epub 2006 Oct 2.
By continuous monitoring of abdominal aortic blood pressure via telemetry in conscious rats, we have observed that systolic, diastolic, and pulse pressures of male Brown-Norway rats were all significantly lower than that of male Wistar-Kyoto rats, despite the fact that all of the values in both strains were within normotensive ranges. Further analyses performed in 166 animals from the progeny of an F2 intercross between Brown-Norway and Wistar-Kyoto rats revealed that, despite a high correlation between systolic blood pressure and diastolic blood pressure, there was no correlation between pulse pressure and diastolic blood pressure, and the value of the correlation between systolic blood pressure and pulse pressure was lower than that of systolic blood pressure with diastolic blood pressure. Two major and highly significant (P<0.001) quantitative trait loci linked to pulse pressure were found on chromosome 4 (Pp1) and 16 (Pp2). Only suggestive quantitative trait loci were found for systolic blood pressure, but the strongest one (Sbp1) had the same peak and linkage probability profile as Pp1. Altogether, these data show that genetic determinants affecting pulse pressure in normotensive animals are either stronger or independent from the ones affecting systolic blood pressure and are of interest in light of evidence showing that pulse pressure is highly heritable in humans and that elevated pulse pressure is a predictor of cardiovascular risk.
通过对清醒大鼠进行遥测连续监测腹主动脉血压，我们观察到，尽管两种品系的所有数值均在正常血压范围内，但雄性布朗挪威大鼠的收缩压、舒张压和脉压均显著低于雄性Wistar-Kyoto大鼠。对166只来自布朗挪威大鼠和Wistar-Kyoto大鼠F2杂交后代的动物进行的进一步分析显示，尽管收缩压和舒张压之间存在高度相关性，但脉压与舒张压之间无相关性，且收缩压与脉压之间的相关值低于收缩压与舒张压之间的相关值。在4号染色体（Pp1）和16号染色体（Pp2）上发现了两个与脉压相关的主要且高度显著（P<0.001）的数量性状基因座。仅发现了提示性的收缩压数量性状基因座，但最强的一个（Sbp1）与Pp1具有相同的峰值和连锁概率图谱。总之，这些数据表明，影响正常血压动物脉压的遗传决定因素要么比影响收缩压的因素更强，要么与之独立，鉴于有证据表明脉压在人类中具有高度遗传性，且脉压升高是心血管风险的预测指标，这些发现具有重要意义。
