结节病患者中18F-FDG PET与67Ga闪烁扫描术的对比评估

Comparative evaluation of 18F-FDG PET and 67Ga scintigraphy in patients with sarcoidosis.

作者信息

Nishiyama Yoshihiro, Yamamoto Yuka, Fukunaga Kotaro, Takinami Hiroyuki, Iwado Yasuyoshi, Satoh Katashi, Ohkawa Motoomi

机构信息

Department of Radiology, Faculty of Medicine, Kagawa University, Kagawa, Japan.

出版信息

J Nucl Med. 2006 Oct;47(10):1571-6.

PMID:17015889

Abstract

UNLABELLED

67Ga scintigraphy has been used for years in sarcoidosis for diagnosis and the extent of the disease. However, little information is available on the comparison of 18F-FDG PET and 67Ga scintigraphy in the assessment of sarcoidosis. The purpose of this study was to compare the uptake of 18F-FDG and 67Ga in the evaluation of pulmonary and extrapulmonary involvement in patients with sarcoidosis.

METHODS

Eighteen patients with sarcoidosis were examined. 18F-FDG PET was performed at 1 h after injection of 185-200 MBq 18F-FDG. 67Ga whole-body planar and thoracic SPECT images were acquired 72 h after injection of 111 MBq 67Ga. We evaluated 18F-FDG and 67Ga uptake visually and semiquantitatively using standardized uptake values (SUVs) and the ratio of lesion to normal lumbar spine (L/N ratio), respectively. The presence of pulmonary and extrapulmonary lesions was evaluated histopathologically or by the radiologic findings.

RESULTS

Five patients had only pulmonary lesions, 12 patients had both pulmonary and extrapulmonary lesions, and 1 patient had only an extrapulmonary lesion. Both 67Ga planar and SPECT images detected 17 of 21 (81%) clinically observed pulmonary sites. The mean +/- SD of the L/N ratio was 1.97 +/- 1.09. 67Ga planar images detected 15 of 31 (48%) clinically observed extrapulmonary sites. The mean +/- SD of the L/N ratio was 1.17 +/- 0.33. 18F-FDG PET detected all 21 (100%) clinically observed pulmonary sites. The mean +/- SD of the SUV was 7.40 +/- 2.48. 18F-FDG PET detected 28 of 31 (90%) clinically observed extrapulmonary sites. The mean +/- SD of the SUV was 5.90 +/- 2.75.

CONCLUSION

The results of this clinical study suggest that 18F-FDG PET can detect pulmonary lesions to a similar degree as 67Ga scintigraphy. However, 18F-FDG PET appears to be more accurate and contributes to a better evaluation of extrapulmonary involvement in sarcoidosis patients.

摘要

未标注

多年来，67Ga闪烁显像一直用于结节病的诊断及病情评估。然而，关于18F-FDG PET与67Ga闪烁显像在结节病评估中的比较，相关信息较少。本研究的目的是比较18F-FDG和67Ga在结节病患者肺内及肺外受累情况评估中的摄取情况。

方法

对18例结节病患者进行检查。注射185 - 200 MBq 18F-FDG后1小时行18F-FDG PET检查。注射111 MBq 67Ga后72小时采集67Ga全身平面及胸部SPECT图像。我们分别使用标准化摄取值（SUV）和病变与正常腰椎的比值（L/N比值）对18F-FDG和67Ga摄取进行视觉和半定量评估。通过组织病理学或影像学检查结果评估肺内及肺外病变的存在情况。

结果

5例患者仅有肺部病变，12例患者既有肺部病变又有肺外病变，1例患者仅有肺外病变。67Ga平面及SPECT图像检测到21个临床观察到的肺部病灶中的17个（81%）。L/N比值的均值±标准差为1.97±1.09。67Ga平面图像检测到31个临床观察到的肺外病灶中的15个（48%）。L/N比值的均值±标准差为1.17±0.33。18F-FDG PET检测到所有21个（100%）临床观察到的肺部病灶。SUV的均值±标准差为7.40±2.48。18F-FDG PET检测到31个临床观察到的肺外病灶中的28个（90%）。SUV的均值±标准差为5.90±2.75。