用64CuCl2摄取增加的小鼠人前列腺癌异种移植模型的正电子发射断层显像（PET）
PET of human prostate cancer xenografts in mice with increased uptake of 64CuCl2.
作者信息
Peng Fangyu, Lu Xin, Janisse James, Muzik Otto, Shields Anthony F
机构信息
Department of Pediatrics, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA.
出版信息
J Nucl Med. 2006 Oct;47(10):1649-52.
UNLABELLED
Our objective was to determine whether human prostate cancer xenografts in mice can be localized by PET using 64CuCl2 as a probe (64Cu PET).
METHODS
Athymic mice bearing human prostate cancer xenografts were subjected to 64Cu PET, followed by quantitative analysis of the tracer concentrations and immunohistochemistry study of human copper transporter 1 expression in the tumor tissues.
RESULTS
Human prostate cancer xenografts expressing high levels of human copper transporter 1 were well visualized on the PET images obtained 24 h after injection but not on the images obtained 1 h after injection. PET quantitative analysis demonstrated a high concentration of 64CuCl2 in the tumors in comparison to that in the left shoulder regions (percentage injected dose per gram of tissue: 3.6 +/- 1.3 and 0.6 +/- 0.3, respectively; P = 0.004), at 24 h after injection.
CONCLUSION
The data from this study suggested that locally recurrent prostate cancer might be localized with 64Cu PET using 64CuCl2 as a probe.
未标记
我们的目的是确定使用64CuCl2作为探针的PET（64Cu PET）是否能够定位小鼠体内的人前列腺癌异种移植瘤。
方法
对携带人前列腺癌异种移植瘤的无胸腺小鼠进行64Cu PET检查，随后对示踪剂浓度进行定量分析，并对肿瘤组织中人铜转运蛋白1的表达进行免疫组织化学研究。
结果
在注射后24小时获得的PET图像上，高表达人铜转运蛋白1的人前列腺癌异种移植瘤清晰可见，但在注射后1小时获得的图像上则不可见。PET定量分析表明，与左肩部区域相比，注射后24小时肿瘤内64CuCl2浓度较高（每克组织注射剂量百分比：分别为3.6±1.3和0.6±0.3；P = 0.004）。
结论
本研究数据表明，使用64CuCl2作为探针的64Cu PET可能定位局部复发性前列腺癌。
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