Yoneda K, Mason R L, McKinney S, Pulmano C
Department of Pathology, Veterans Administration Medical Center, Lexington, Kentucky 40511.
Acta Cytol. 1990 Nov-Dec;34(6):797-800.
A light and electron microscopic study was conducted to investigate nuclear changes observed in specimens obtained from various sites by computed tomographic (CT)-guided fine needle aspiration (FNA) biopsy. These changes, which consisted of a disappearance of the nuclear chromatin and a disruption of the nuclear membrane, were found in 70% of 10 FNA specimens obtained with CT guidance, in 26% of 15 specimens obtained with fluoroscopic guidance and in 0% of 10 specimens obtained without x-ray imaging techniques. Although the number of cases studied was small and the mechanisms responsible for these changes are not clear, cytopathologists should be aware of alterations in evaluating FNA specimens obtained with the guidance of x-ray imaging techniques.
进行了一项光镜和电镜研究，以调查通过计算机断层扫描（CT）引导下细针穿刺抽吸（FNA）活检从不同部位获取的标本中观察到的核变化。这些变化包括核染色质消失和核膜破裂，在CT引导下获取的10例FNA标本中有70%出现这些变化，在透视引导下获取的15例标本中有26%出现这些变化，而在没有使用X射线成像技术获取的10例标本中则为0%。尽管研究的病例数量较少，且导致这些变化的机制尚不清楚，但细胞病理学家在评估X射线成像技术引导下获取的FNA标本时应注意这些改变。
