Urasaki Eiichirou, Genmoto Tetsuya, Yokota Akira, Maeda Rieko, Akamatsu Naoki
Department of Neurosurgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu City, Japan.
J Clin Neurophysiol. 2006 Oct;23(5):426-30. doi: 10.1097/01.wnp.0000186217.15904.99.
To determine the characteristics of high-frequency oscillations (HFOs) of cortical somatosensory evoked potentials (SEPs), the effect of general anesthesia on HFOs and low-frequency primary cortical responses was studied. The authors recorded SEPs elicited by median nerve stimulation directly from human brains of seven patients who underwent implantation of subdural electrodes before surgical treatment of intractable epilepsy. Recordings were made before and during general anesthesia. Changes in the number of HFOs and amplitude ratios of HFOs/primary cortical responses were analyzed. Under general anesthesia, the number of HFO peaks and the amplitude ratios were significantly decreased. General anesthesia induced remarkably decreased HFO activities when compared to low-frequency SEPs, suggesting that each of those originated from different generators. Possible relations between gamma-amino-butyric acid (GABA)ergic inhibitory interneurons and HFOs are discussed.
为了确定皮质体感诱发电位（SEPs）的高频振荡（HFOs）特征，研究了全身麻醉对HFOs和低频初级皮质反应的影响。作者直接从7例顽固性癫痫手术治疗前接受硬膜下电极植入的患者大脑中记录了正中神经刺激诱发的SEPs。记录在全身麻醉前和麻醉期间进行。分析了HFOs数量和HFOs/初级皮质反应振幅比的变化。在全身麻醉下，HFO峰值数量和振幅比显著降低。与低频SEPs相比，全身麻醉导致HFO活动显著降低，表明它们各自起源于不同的发生器。讨论了γ-氨基丁酸（GABA）能抑制性中间神经元与HFOs之间的可能关系。
