Sengupta S, Fine J, Wu-Wang C Y, Gordon J, Murty V L, Slomiany A, Slomiany B L
Research Center, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, Newark 07103.
Arch Oral Biol. 1990;35(8):593-6. doi: 10.1016/0003-9969(90)90024-5.
Gingival crevicular fluid, collected from 8 patients with chronic adult periodontitis before and 21 days after root planing and scaling, was analysed for prostaglandin E2, 6KPGF1 alpha, cAMP, IgG, IgM and alpha-2-macroglobulin, and their inter-relationship evaluated. There was a significant decrease in the levels of prostaglandin E2, IgG, IgM and alpha-2-macroglobulin after treatment, whereas the levels of 6KPGF1 alpha and cAMP remained essentially unchanged. The level of prostaglandin E2 decreased by 35%, IgG by 32%, IgM by 90%, and alpha-2-macroglobulin by 79%. There was a significant degree of correlation between prostaglandin E2 and 6KPGF1 alpha and cAMP before treatment but not after, but no correlation between prostaglandin E2 and IgG, IgM and alpha-2-macroglobulin either before or after. This correlation pattern indicates the involvement of E2, prostaglandin 6KPGF1 alpha and cAMP in inflammation in the periodontium. The changes in IgG, IgM and alpha-2-macroglobulin reflect yet another mechanism of host response which appears to be independent of prostaglandins.
从8例慢性成人牙周炎患者在根面平整和刮治前及治疗后21天收集龈沟液，分析其中前列腺素E2、6 -酮-前列腺素F1α、环磷酸腺苷（cAMP）、免疫球蛋白G（IgG）、免疫球蛋白M（IgM）和α2 -巨球蛋白，并评估它们之间的相互关系。治疗后前列腺素E2、IgG、IgM和α2 -巨球蛋白水平显著下降，而6 -酮-前列腺素F1α和cAMP水平基本保持不变。前列腺素E2水平下降了35%，IgG下降了32%，IgM下降了90%，α2 -巨球蛋白下降了79%。治疗前前列腺素E2与6 -酮-前列腺素F1α和cAMP之间存在显著相关性，但治疗后无相关性，且无论治疗前后，前列腺素E2与IgG、IgM和α2 -巨球蛋白之间均无相关性。这种相关性模式表明前列腺素E2、6 -酮-前列腺素F1α和cAMP参与了牙周组织的炎症反应。IgG、IgM和α2 -巨球蛋白的变化反映了宿主反应的另一种机制，这种机制似乎独立于前列腺素。
