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Implications for eicosapentaenoic acid- and docosahexaenoic acid-derived resolvins as therapeutics for arthritis.二十碳五烯酸和二十二碳六烯酸衍生的消退素作为关节炎治疗药物的意义。
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局部口服1-十四烷醇复合物治疗猫牙周疾病

Topical oral 1-tetradecanol complex in the treatment of periodontal diseases in cats.

作者信息

Lopes Kubitza Fernanda Maria, Anthony James Mudie George

机构信息

Campos de Santo Antonio, Itu, São Paulo, Brazil.

Red Bank Veterinary Hospital, Dentistry and Oral Surgery, Red Bank, NJ, USA.

出版信息

J Feline Med Surg. 2019 Dec;21(12):1141-1148. doi: 10.1177/1098612X18820734. Epub 2019 Jan 17.

DOI:10.1177/1098612X18820734
PMID:30652935
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10814267/
Abstract

OBJECTIVES

The aim of this study was to evaluate the outcomes of the treatment of chronic periodontal disease with an oral application of tetradecanol complex (1-TDC) in cats.

METHODS

The test group (n = 9) received 1-TDC (525 mg per gel capsule/day) and the placebo group (n = 4) received olive oil (0.25 ml per gel capsule/day) for 6 weeks.

RESULTS

Oral treatment with 1-TDC resulted in significant reductions in all parameters of clinical periodontal disease except tooth mobility at 6 weeks. The 1-TDC group exhibited a statistically significant reduction in pocket depth, clinical attachment loss, gingival index and bleeding on probing after treatment at 6 weeks, whereas the placebo group did not show any significant change.

CONCLUSIONS AND RELEVANCE

Chronic inflammation associated with periodontal diseases leads to periodontal tissue destruction. As a result, modulation of the host response has been included in the treatment protocol for periodontal diseases. Fatty acids present anti-inflammatory properties and are being investigated for use in the treatment and prevention of progressive periodontal diseases.

摘要

目的

本研究旨在评估口服十四烷醇复合物（1-TDC）治疗猫慢性牙周病的效果。

方法

试验组（n = 9）接受1-TDC（每粒凝胶胶囊525毫克/天），安慰剂组（n = 4）接受橄榄油（每粒凝胶胶囊0.25毫升/天），为期6周。

结果

口服1-TDC导致除6周时牙齿松动外，临床牙周病的所有参数均显著降低。1-TDC组在治疗6周后，牙周袋深度、临床附着丧失、牙龈指数和探诊出血均有统计学意义的显著降低，而安慰剂组未显示任何显著变化。

结论及意义

与牙周病相关的慢性炎症会导致牙周组织破坏。因此，调节宿主反应已被纳入牙周病的治疗方案。脂肪酸具有抗炎特性，正在研究其用于治疗和预防进展性牙周病。