Sartipy Peter, Bjorquist Petter, Strehl Raimund, Hyllner Johan
Cellartis AB, Arvid Wallgrens Backe 20, 413 46 Göteborg, Sweden.
IDrugs. 2006 Oct;9(10):702-5.
Improved technologies are urgently needed to develop effective and safe new drugs in a cost-efficient manner. Cell-based assays have many advantages in drug research, particularly because these assays can be adapted in a high-throughput format. In addition, technological advances in the areas of instrumentation and automation are providing expanding opportunities for high-content analyses. However, in cell-based research, none of these systems is particularly useful unless the cells that are being evaluated are clinically relevant. Pluripotent human stem cells are expected to revolutionize the accessibility to a variety of human cell types. The possibility to propagate pluripotent human stem cells and to subsequently differentiate these cells into desired target cell types will provide a stable supply of cells for a range of applications in drug discovery and toxicity testing. This feature discusses some of the research opportunities for pluripotent human stem cells.
迫切需要改进技术，以便以具有成本效益的方式开发有效且安全的新药。基于细胞的检测在药物研究中具有许多优势，特别是因为这些检测可以采用高通量形式。此外，仪器仪表和自动化领域的技术进步为高内涵分析提供了越来越多的机会。然而，在基于细胞的研究中，除非所评估的细胞具有临床相关性，否则这些系统都没有特别大的用处。多能人类干细胞有望彻底改变获取各种人类细胞类型的途径。多能人类干细胞的增殖以及随后将这些细胞分化为所需靶细胞类型的可能性，将为药物发现和毒性测试中的一系列应用提供稳定的细胞供应。本专题讨论了多能人类干细胞的一些研究机会。
