Mayoral F, Polo V, Ferreras A, Larrosa J M, Pueyo V, Honrubia F
Hospital Universitario Miguel Servet de Zaragoza, Po. Isabel la Católica 1-3, 50009 Zaragoza, Spain.
Arch Soc Esp Oftalmol. 2006 Sep;81(9):537-44. doi: 10.4321/s0365-66912006000900009.
To compare retinal nerve fiber layer (RNFL) measurements performed with Stratus OCT 3000 in normal, ocular hypertensive, pre-perimetric and glaucomatous eyes.
98 normal subjects, 156 ocular hypertensives with short-wavelength automated perimetry (SWAP), 21 ocular hypertensives with altered SWAP (pre-perimetric glaucoma) and 66 glaucomatous eyes were included in the study. Diagnostic groups were classified based on intraocular pressure, optic nerve head appearance, achromatic automatic perimetry and SWAP. RNFL parameters were obtained using a Stratus OCT 3000 (Humphrey Zeiss instruments). RNFL measurements were compared among the groups.
RNFL average thickness, superior, inferior and nasal quadrant thickness, and each 12 clock-hour positions except for H9, H10 and H11 showed significant differences between glaucomatous and pre-perimetric glaucoma eyes. RNFL average thickness, inferior quadrant and H10 clock-hour position showed significant differences between normal and ocular hypertensive subjects. Pre-perimetric glaucomas and ocular hypertensives showed differences in H11 clock-hour position exclusively.
RNFL measurements performed using Stratus OCT showed differences between the study groups. OCT may be as useful as SWAP in early glaucoma diagnosis.
比较使用Stratus OCT 3000对正常眼、高眼压症眼、视野检查前青光眼和青光眼患者进行的视网膜神经纤维层（RNFL）测量。
本研究纳入98名正常受试者、156名接受短波长自动视野计（SWAP）检查的高眼压症患者、21名SWAP结果异常（视野检查前青光眼）的高眼压症患者以及66只青光眼患眼。根据眼压、视神经乳头外观、无色觉自动视野计和SWAP对诊断组进行分类。使用Stratus OCT 3000（汉弗莱蔡司仪器）获取RNFL参数。对各组之间的RNFL测量结果进行比较。
青光眼和视野检查前青光眼患眼之间，RNFL平均厚度、上、下、鼻侧象限厚度以及除H9、H10和H11外的每个12个钟点位置均存在显著差异。正常受试者和高眼压症患者之间，RNFL平均厚度、下象限和H10钟点位置存在显著差异。仅在H11钟点位置，视野检查前青光眼和高眼压症患者之间存在差异。
使用Stratus OCT进行的RNFL测量显示各研究组之间存在差异。OCT在早期青光眼诊断中可能与SWAP一样有用。
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