Carrera O, Gutiérrez E, Boakes R A
Universidad de Santiago, Santiago de Compostela, Spain.
Dev Psychobiol. 2006 Nov;48(7):520-7. doi: 10.1002/dev.20175.
Resistance to restricted feeding with and without wheel access was tested in rats handled (H) for 20 days since birth. Weight loss produced by 1.5-hr restricted food access was less in H than in non-handled (NH) males when tested aged 41 days. At this age combining food restriction with access to a running wheel (a procedure commonly known as activity-based anorexia, ABA) produced very rapid weight loss and no effect of handling was detected. When 75-day females were tested in the same way, under the ABA procedure H rats took longer than NH controls to reach the removal criterion. Simply restricting food access in these females produced variable weight loss, without detection of any handling effect. No differences in food intake or running were detected between H and NH rats in either males or females. In conclusion, handling seems to have a direct effect on rats' later response to either food deprivation alone or to an ABA procedure.
对自出生起就接受了20天处理（H组）的大鼠进行了有无转轮情况下限食的抗性测试。在41日龄时进行测试，1.5小时限食导致的体重减轻在H组雄性大鼠中比未处理（NH组）雄性大鼠中要少。在这个年龄，将食物限制与使用转轮相结合（一种通常称为基于活动的厌食症，ABA的程序）会导致体重非常迅速地减轻，并且未检测到处理的影响。当以同样的方式对75日龄雌性大鼠进行测试时，在ABA程序下，H组大鼠比NH组对照达到移除标准所需的时间更长。单纯对这些雌性大鼠进行食物限制会导致体重减轻情况不一，未检测到任何处理效果。在雄性和雌性大鼠中，H组和NH组在食物摄入量或运动量方面均未检测到差异。总之，处理似乎对大鼠后来单独对食物剥夺或ABA程序的反应有直接影响。
