Smorodinova Iu V, Shcherbaniuk A I, Ryzhko I V, Moldavan I A
Antibiot Khimioter. 2005;50(8-9):23-6.
The efficacy of isepamycin vs. other aminoglycosides was studied in vitro and on albino mice with experimental plague due to natural antigen valuable strains of the plague microbe and the pathogen variants deprived of the ability to produce the capsular antigen fraction I (FI- phenotype). The MICs of isepamycin for the strains of the plague microbe (20 FI+ and 20FI-) were 1.0-4.0 mg\l, that did not differ from those of streptomycin, kanamycin, amikacin and tobramycin. The ED50 of isepamycin in the prophylaxis and treatment of the experimental plague of the mice had no statistically significant differences from the ED50 of the other aminoglycosides. The efficacy index of isepamycin was > 10(4), that did not differ from that of streptomycin, amikacin and gentamicin, irrespective of the strain phenotype (Y. pestis 231 FI+ or Y. pestis 231 FI-). The same as the other aminoglycosides, isepamycin in doses equivalent to the human average daily doses, protected 80-100% of the albino mice from death when used in the prophylaxis and therapy of plague irrespective of the strain phenotype. The results of the study made it possible to consider isepamycin as an agent promising for the prophylaxis and treatment of plague.
在体外以及对白化小鼠进行研究，比较异帕米星与其他氨基糖苷类药物对鼠疫的疗效。这些小鼠感染了由鼠疫杆菌天然抗原珍贵菌株以及丧失产生荚膜抗原I组分能力的病原体变体（FI-表型）引起的实验性鼠疫。异帕米星对鼠疫杆菌菌株（20株FI+和20株FI-）的最低抑菌浓度为1.0 - 4.0mg/L，与链霉素、卡那霉素、阿米卡星和妥布霉素的最低抑菌浓度无差异。异帕米星在预防和治疗小鼠实验性鼠疫中的半数有效剂量与其他氨基糖苷类药物的半数有效剂量相比，无统计学显著差异。异帕米星的效价指数>10(4)，与链霉素、阿米卡星和庆大霉素的效价指数无差异，无论菌株表型如何（鼠疫耶尔森菌231 FI+或鼠疫耶尔森菌231 FI-）。与其他氨基糖苷类药物一样，异帕米星在相当于人类平均日剂量的情况下，用于鼠疫的预防和治疗时，无论菌株表型如何，均可保护80 - 100%的白化小鼠免于死亡。该研究结果使人们有可能将异帕米星视为一种有前景的鼠疫预防和治疗药物。
