Ryzhko I V, Samokhodkina E D, Tsuraeva R I, Shcherbaniuk A I, Tsetskhladze N S
Research Plague Institute, Rostov-on-Don.
Antibiot Khimioter. 1998;43(9):24-8.
The efficacy of various group antibacterial drugs: aminoglycosides, quinolones, 3rd generation cephalosporins, doxycycline, rifampicin, ampicillin and azthreonam was estimated in the treatment of experimental plague of albino mice induced by antigen complete and atypical strains of the F1- phenotype plague microbe. The in vitro experiments showed that all the strains of the plague microbe irrespective of the phenotype (F1+ or F1-) were highly susceptible to the drugs. The animal experiments demonstrated that aminoglycosides (streptomycin, kanamycin, tobramycin, gentamicin and amikacin) and cephalosporins (ceftriaxone and ceftazidim) were highly efficient in the prophylaxis and treatment of plague due to F1+ and F1- strains. In experimental plague due to F1- phenotype plague microbe the prophylactic effects of cefotaxime, cefoperazone, sulbactam/ampicillin, azthreonam, ciprofloxacin and rifampicin were lower. However, increase of the daily doses of the drugs and prolongation of the treatment course up to 7 days made it possible to increase the protective effects up to 80-100 per cent. Doxycycline and ampicillin were not sufficiently efficient even when used for 10 days in the prophylaxis of plague due to F1- strains.
评估了各类抗菌药物（氨基糖苷类、喹诺酮类、第三代头孢菌素、强力霉素、利福平、氨苄西林和氨曲南）在治疗由抗原完全型和非典型F1表型鼠疫杆菌菌株诱导的白化小鼠实验性鼠疫中的疗效。体外实验表明，所有鼠疫杆菌菌株，无论其表型（F1+或F1-），对这些药物都高度敏感。动物实验证明，氨基糖苷类（链霉素、卡那霉素、妥布霉素、庆大霉素和阿米卡星）和头孢菌素（头孢曲松和头孢他啶）在预防和治疗由F1+和F1-菌株引起的鼠疫方面非常有效。在由F1-表型鼠疫杆菌引起的实验性鼠疫中，头孢噻肟、头孢哌酮、舒巴坦/氨苄西林、氨曲南、环丙沙星和利福平的预防效果较低。然而，增加药物的每日剂量并将治疗疗程延长至7天，可使保护效果提高至80%-100%。即使在预防由F1-菌株引起的鼠疫时使用10天，强力霉素和氨苄西林的效果也不够理想。
