Makaju Ramesh Kumar, Tamang Migma Dorji, Sharma Yubaraj, Sharma Nastu, Koju Rajendra, Bedi Tikka Ramesh Singh, Khanal Sharad
Department of Pathology, Kathmandu University Medical School, Kathmandu University Teaching Hospital Dhulikhel, Kavre, Nepal.
Nepal Med Coll J. 2006 Jun;8(2):97-100.
The main objective of this study was to determine whether a homemade rapid urease test was reliable when compared to histology in the diagnosis of Helicobacter pylori infection. Endoscopic antral biopsies from 15th August 2004 to 15th July 2005 were studied prospectively. Rapid urease test and histological examination were done on all specimens. Among 160 biopsies, 56 cases showed H. pylori in histological section and 59 cases were rapid urease test positive. Among 56 H. pylori infected patients, the sensitivity, specificity, positive and negative predictive values, percentage of false positive, and percentage of false negative values of rapid urease test were 96.4%, 95.2%, 91.5%, 98.0%, 4.8% and 3.5% respectively. Rapid urease test is positive in significantly higher number (p < 0.001) in histological positive cases. In conclusion our homemade rapid urease test is a test with good sensitivity and specificity for detection of H. pylori infection.
本研究的主要目的是确定与组织学检查相比，自制快速尿素酶试验在诊断幽门螺杆菌感染时是否可靠。对2004年8月15日至2005年7月15日期间的内镜下胃窦活检标本进行前瞻性研究。对所有标本进行快速尿素酶试验和组织学检查。在160份活检标本中，组织学切片显示56例有幽门螺杆菌，59例快速尿素酶试验呈阳性。在56例幽门螺杆菌感染患者中，快速尿素酶试验的敏感性、特异性、阳性和阴性预测值、假阳性率和假阴性率分别为96.4%、95.2%、91.5%、98.0%、4.8%和3.5%。组织学阳性病例中快速尿素酶试验呈阳性的数量显著更高（p < 0.001）。总之，我们自制的快速尿素酶试验是一种检测幽门螺杆菌感染具有良好敏感性和特异性的试验。
