Jogai Sanjay, Dey Pranab, Al Jassar Aisha, Amanguno H G, Adesina Aaron O
Departments of Cytology and Histopathology, Kuwait Cancer Control Center, Shuwaikh, Kuwait.
Acta Cytol. 2006 Sep-Oct;50(5):507-12. doi: 10.1159/000326004.
To assess the efficacy of fine needle aspiration cytology (FNAC) in the diagnosis of nodular sclerosis variant of Hodgkin's lymphoma (NSHL) and to analyze cytologic features that could help in subtyping a case of Hodgkin's lymphoma into this variant.
FNAC smears of 18 histopathologically proven cases of NSHL were analyzed for a variety of features.
On initial cytologic assessment, 14 of 18 cases were diagnosed as Hodgkin's lymphoma. No further subtyping was performed. In this retrospective analysis it was possible to revise the diagnosis in the remaining 4 cases. Of the various cytologic features analyzed, presence of numerous lacunar-type cells along with fibroblasts and collagenous material were useful pointers toward a diagnosis of nodular sclerosis variant. Fibroblasts were seen in 83.33%, collagenous material in 27.77% and numerous lacunar cells in 77.77%.
Subtyping of NSHL based on cytologic features alone has been a matter of debate for a long time. Of the various subtypes, nodular sclerosis poses the greatest diagnostic difficulty. Though certain cytologic features may help in suggesting a diagnosis of nodular sclerosis variant, the primary role of fine needle aspiration is to diagnose a case of Hodgkin's lymphoma as such and advise histopathologic examination for further categorization.
评估细针穿刺细胞学检查（FNAC）在结节硬化型霍奇金淋巴瘤（NSHL）诊断中的效能，并分析有助于将霍奇金淋巴瘤病例亚型诊断为该型的细胞学特征。
对18例经组织病理学证实的NSHL病例的FNAC涂片进行多种特征分析。
在初始细胞学评估中，18例中有14例被诊断为霍奇金淋巴瘤。未进行进一步的亚型分类。在这项回顾性分析中，其余4例的诊断得以修正。在所分析的各种细胞学特征中，大量陷窝细胞与成纤维细胞及胶原物质的存在是诊断结节硬化型的有用指标。成纤维细胞见于83.33%的病例，胶原物质见于27.77%的病例，大量陷窝细胞见于77.77%的病例。
长期以来，仅基于细胞学特征对NSHL进行亚型分类一直存在争议。在各种亚型中，结节硬化型的诊断难度最大。尽管某些细胞学特征可能有助于提示结节硬化型的诊断，但细针穿刺的主要作用是诊断霍奇金淋巴瘤病例本身，并建议进行组织病理学检查以进一步分类。
