Stanley M W, Powers C N
Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Little Rock 72205, USA.
Diagn Cytopathol. 1997 Dec;17(6):477-9. doi: 10.1002/(sici)1097-0339(199712)17:6<477::aid-dc19>3.0.co;2-j.
The syncytial variant is a recently described, uncommon form of nodular sclerosing Hodgkin's disease that was previously termed "sarcomatoid." In addition to foci of typical sclerosis, it is characterized histologically by sheets or clusters of mononuclear Reed-Sternberg variants. These may be arranged around areas of necrosis with variable numbers of neutrophils. In excised material, differential diagnostic considerations include non-Hodgkin's malignant lymphoma, granulocytic sarcoma, malignant melanoma, metastatic carcinoma, thymoma, and metastatic germ cell tumor. We describe the fine-needle aspiration cytologic finding in two examples of this entity. Cohesive clusters and sheets of malignant cells with clear cytoplasm, vesicular nuclei, and prominent nucleoli are easily mistaken for metastatic carcinoma or germ cell tumor. Ancillary tests useful in this differential diagnosis are discussed.
合体细胞变异型是一种最近才被描述的、不常见的结节硬化型霍奇金淋巴瘤，以前被称为“肉瘤样”。除了典型硬化灶外，其组织学特征是单核Reed-Sternberg变异型细胞成片或成簇分布。这些细胞可围绕坏死区域排列，伴有数量不等的中性粒细胞。在切除的组织中，鉴别诊断需考虑非霍奇金恶性淋巴瘤、粒细胞肉瘤、恶性黑色素瘤、转移性癌、胸腺瘤和转移性生殖细胞肿瘤。我们描述了该实体两个病例的细针穿刺细胞学表现。具有透明细胞质、泡状核和明显核仁的恶性细胞黏附性团块和片层很容易被误诊为转移性癌或生殖细胞肿瘤。本文讨论了有助于该鉴别诊断的辅助检查。
