Pfeiffer David F, Bode-Lesniewska Beata
Institute of Clinical Pathology, University Hospital, Zurich, Switzerland.
Acta Cytol. 2006 Sep-Oct;50(5):553-6. doi: 10.1159/000326014.
Angiosarcoma is a rare malignant soft tissue tumor occurring at various sites as either a primary or secondary event. Primary angiosarcoma of the breast is an unusual tumor, counting for 1 in 1700-2,000 primary malignant tumors of this organ. An increasing number of secondary angiosarcomas involving skin and breast.
Angiosarcoma arose 6 years after breast-conserving therapy for invasive carcinoma in a 69-year-old woman. Fine needle aspiration of several small, reddish, intradermal nodules over the treated area revealed malignant cells with an endothelial immunophenotype in the cel block, yielding the diagnosis of angiosarcoma, subsequently confired in a mastectomy speciman.
Fine needle aspiration, supported by ancillary techniques, such as cell block and immunohistochemistry, allows the cytologic diagnosis of an angiosarcoma and differentiates it from a carcinoma recurrence.
血管肉瘤是一种罕见的恶性软组织肿瘤，可原发或继发于身体的各个部位。乳腺原发性血管肉瘤是一种不常见的肿瘤，在该器官的原发性恶性肿瘤中占1/1700 - 2000。越来越多的继发性血管肉瘤累及皮肤和乳腺。
一名69岁女性在保乳治疗浸润性癌6年后发生血管肉瘤。对治疗区域出现的几个小红皮内结节进行细针穿刺活检，细胞块显示具有内皮免疫表型的恶性细胞，诊断为血管肉瘤，随后在乳房切除标本中得到证实。
在细胞块和免疫组织化学等辅助技术支持下的细针穿刺活检，能够对血管肉瘤进行细胞学诊断，并将其与癌复发相鉴别。
