Di Tommaso L, Fabbri A
Dipartimento di Oncologia, Sezione di Anatomia Patologica Marcello Malpighi, Ospedale Bellaria, Università di Bologna, via Altura 3, 40139 Bologna.
Pathologica. 2003 Aug;95(4):196-202.
Cutaneous angiosarcomas occurring as a complication of radiation therapy for breast cancer are rare. To the best of our knowledge 37 cases have been reported in English literature during the last two decades. We describe a case of angiosarcoma arising in the skin of a breast previously irradiated for breast carcinoma. The patient, a 74-year-old woman, had been treated with conservative surgery and radiotherapy for a pT1N0 infiltrating ductal carcinoma of the left breast in 1993. Nine years later a skin lesion, which was interpreted as a recurrence, arose in the same site. A biopsy obtained from the lesion, and initially considered to be negative for cancer, showed istological features consistent with those of the atypical vascular lesion. Seven months later the same lesion transformed in a 5 x 3 reddish mass which at histological examination was diagnosed as an high grad post-irradiation angiosarcoma of the skin of the breast. Data on previously reported post iradiation angiosarcoma of the breast are reviewed; further consideration on differential diagnosis between those lesions and atypical vascular lesions are presented.
作为乳腺癌放射治疗并发症出现的皮肤血管肉瘤很罕见。据我们所知，在过去二十年的英文文献中已报道了37例。我们描述了一例血管肉瘤，发生于先前因乳腺癌接受过放射治疗的乳房皮肤。患者为一名74岁女性，1993年因左乳pT1N0浸润性导管癌接受了保守手术和放射治疗。九年后，同一部位出现了一个皮肤病变，最初被认为是复发。从该病变处获取的活检标本，最初被认为癌症检测呈阴性，但其组织学特征与非典型血管病变一致。七个月后，同一病变转变为一个5×3厘米的红色肿块，组织学检查诊断为乳房皮肤高分级放疗后血管肉瘤。我们回顾了先前报道的乳房放疗后血管肉瘤的数据；并对这些病变与非典型血管病变之间鉴别诊断的进一步思考进行了阐述。
