Scalzo Karen, Plebanski Magdalena, Apostolopoulos Vasso
Vaccine and Infectious Disease Laboratory, Burnet Institute at Austin, Studley Rd, Heidelberg Victoria 3084, Australia.
Curr Top Med Chem. 2006;6(16):1759-68. doi: 10.2174/156802606778194262.
Regulation of immune responses is crucial in order to maintain immunological self-tolerance. This is maintained in the periphery by a number of cell types that have the capacity to control and regulate immune responses, thus preventing reactivity to self while monitoring appropriate, non-exuberant responses to non-self-antigens. The various mechanisms of regulation will be discussed in this review together with how this knowledge could be used to develop better drugs and treatments for various diseases.
免疫反应的调节对于维持免疫自身耐受性至关重要。在周围组织中，多种细胞类型可维持这种耐受性，这些细胞能够控制和调节免疫反应，从而在监测对非自身抗原的适当、不过度反应的同时，防止对自身产生反应性。本综述将讨论各种调节机制，以及如何利用这些知识开发针对各种疾病的更好药物和治疗方法。
