Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford School of Medicine, Stanford, CA, USA; Institute for Stem Cell Biology and Regenerative Medicine (ISCBRM), Stanford School of Medicine, Stanford, CA, USA.
San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute Milan, Italy.
Immunity. 2018 Dec 18;49(6):1004-1019. doi: 10.1016/j.immuni.2018.12.001.
Thirty years ago, one of the first types of CD4 T regulatory cells was discovered and named T regulatory type 1 (Tr1) cells. Tr1 cells represent a distinct population of T cells, which are induced in the periphery upon antigen exposure under tolerogenic conditions. They produce the immunosuppressive cytokines interleukin-10 (IL-10) and transforming growth factor-beta (TGF-β), do not constitutively express FOXP3, and suppress the function of effector immune cells. In this review, the key studies leading to the identification and biological characterization of Tr1 cells are recapitulated. The fundamental role of Tr1 cells in regulating immune responses to pathogenic and non-pathogenic antigens, as well as their use as cell therapeutics, is summarized.
三十年前，人们发现并命名了第一种 CD4+T 调节细胞，即调节性 T 细胞 1 型（Tr1）。Tr1 细胞是一种独特的 T 细胞亚群，在耐受条件下，它们在外周抗原暴露时被诱导产生。Tr1 细胞产生抑制性细胞因子白细胞介素-10（IL-10）和转化生长因子-β（TGF-β），不持续表达 FOXP3，并抑制效应免疫细胞的功能。本文总结了导致 Tr1 细胞的鉴定和生物学特征的关键研究，并概括了 Tr1 细胞在调节对致病性和非致病性抗原的免疫反应，以及将其作为细胞治疗中的作用。
