Scabar A, Devescovi R, Blason L, Bravar L, Carrozzi M
Mother-and-Child Referral Hospital and Research Institute, Department of Infantile Neuropsychiatry, Trieste, Italy.
Child Care Health Dev. 2006 Nov;32(6):733-9. doi: 10.1111/j.1365-2214.2006.00705.x.
In children affected by specific language impairment (SLI), many authors have investigated a link between language and epileptiform discharges during sleep resembling the focal sharp waves typical of benign epilepsy with centro-temporal spikes (BECTS), the so-called rolandic spikes. On the other hand, the same electroencephalographic trait occurs in more than 50% of children affected by learning or behavioural disabilities without seizures, supporting the hypothesis of a common genetic disposition. The biological background of Developmental Coordination Disorder (DCD) is currently unknown, but a genetic liability may be assumed. The aims of our study were first to estimate the prevalence of sleep-related epileptiform discharges in children affected by DCD and second to investigate the occurrence of DCD in a population of children affected by BECTS.
We selected a group of eight children with severe DCD. In this group, the presence of epileptiform activity was investigated. We also searched for DCD among a group of 13 children affected by BECTS.
We found rolandic spikes in more than 70% of the children with severe DCD and severe DCD in more than 30% of the children with BECTS.
In children with severe DCD other disabilities are frequently associated. In these children, epileptiform activity during sleep is very frequently found and in our opinion, this represents a hallmark of 'Hereditary Impairment of Brain Maturation', a term only partially resembling 'Atypical Brain Development'.
在患有特定语言障碍（SLI）的儿童中，许多作者研究了睡眠期间语言与癫痫样放电之间的联系，这种放电类似于伴有中央颞部棘波的良性癫痫（BECTS）的局灶性尖波，即所谓的罗兰多棘波。另一方面，超过50%没有癫痫发作的学习或行为障碍儿童也出现了相同的脑电图特征，这支持了共同遗传倾向的假说。发育性协调障碍（DCD）的生物学背景目前尚不清楚，但可能存在遗传易感性。我们研究的目的首先是估计DCD患儿睡眠相关癫痫样放电的患病率，其次是调查BECTS患儿群体中DCD的发生率。
我们选择了一组8名重度DCD儿童。在该组中，调查癫痫样活动的存在情况。我们还在一组13名受BECTS影响的儿童中寻找DCD。
我们发现超过70%的重度DCD儿童有罗兰多棘波，超过30%的BECTS儿童有重度DCD。
在重度DCD儿童中，常伴有其他残疾。在这些儿童中，睡眠期间的癫痫样活动非常常见，我们认为，这是“脑成熟遗传性损害”的一个标志，这一术语仅部分类似于“非典型脑发育”。
