促性腺激素释放激素激动剂对子宫动静脉畸形的作用。
Effect of gonadotropin-releasing hormone agonist on a uterine arteriovenous malformation.
作者信息
Morikawa Mamoru, Yamada Takashi, Yamada Hideto, Minakami Hisanori
机构信息
Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
出版信息
Obstet Gynecol. 2006 Sep;108(3 Pt 2):751-3. doi: 10.1097/01.AOG.0000191584.28717.2c.
BACKGROUND
The effect of gonadotropin-releasing hormone agonist (GnRHa) on uterine arteriovenous malformations (AVM) is not well known.
CASE
A 37-year-old woman with a previous cesarean was diagnosed as having a uterine AVM after a spontaneous abortion with massive vaginal bleeding. The AVM decreased in size from 5.1 x 3.8 cm to 1.4 x 1.0 cm after 6 months of therapy with a GnRHa. Uterine artery embolization conducted after the GnRH therapy resulted in complete disappearance of the AVM. The patient's menstrual cycles and ovulation resumed 3 months after uterine artery embolization.
CONCLUSION
Gonadotropin-releasing hormone agonist therapy reduced the size of the uterine AVM. Thus, GnRHa therapy may be useful for uterine AVM in situations where uterine artery embolization must be postponed.
背景
促性腺激素释放激素激动剂（GnRHa）对子宫动静脉畸形（AVM）的影响尚不清楚。
病例
一名有剖宫产史的37岁女性，在自然流产后出现大量阴道出血，被诊断为子宫AVM。使用GnRHa治疗6个月后，AVM大小从5.1×3.8厘米缩小至1.4×1.0厘米。GnRH治疗后进行的子宫动脉栓塞术使AVM完全消失。子宫动脉栓塞术后3个月，患者月经周期和排卵恢复。
结论
促性腺激素释放激素激动剂治疗减小了子宫AVM的大小。因此，在必须推迟子宫动脉栓塞术的情况下，GnRHa治疗可能对子宫AVM有用。
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