Cohen S P, Abdi S
Walter Reed Army Medical Center, Pain Management Center, Washington, District of Columbia 20307, USA.
Curr Opin Anaesthesiol. 2001 Oct;14(5):505-11. doi: 10.1097/00001503-200110000-00008.
In recent years, tricyclic antidepressant drugs have experienced a resurgence in their use as valuable pharmacological tools in the treatment of pain. Along with the evolution in our understanding of their analgesic mechanisms of action, there have been concurrent breakthroughs regarding their indications for use and modes of administration. This review focuses on recent advances in our understanding of how antidepressant drugs exert their antinociceptive effects, and new developments regarding their clinical application.
近年来，三环类抗抑郁药作为治疗疼痛的重要药理学工具，其使用再度兴起。随着我们对其镇痛作用机制认识的不断发展，在其使用指征和给药方式方面也同时取得了突破。本综述聚焦于我们对抗抑郁药物如何发挥其抗伤害感受作用的最新认识进展，以及其临床应用的新发展。
