Khattari Z, Arbely E, Arkin I T, Salditt T
Institut für Röntgenphysik, Universität Göttingen Friedrich-Hund-Platz 1, 37077 Göttingen, Germany.
Eur Biophys J. 2006 Dec;36(1):45-55. doi: 10.1007/s00249-006-0099-x. Epub 2006 Sep 21.
We have investigated the effect of the transmembrane domain of three viral ion channel proteins on the lipid bilayer structure by X-ray reflectivity and scattering from oriented planar bilayers. The proteins show a similar effect on the lipid bilayer structural parameters: an increase in the lipid bilayer hydrophobic core, a decrease in the amplitude of the vertical density profile and a systematic change in the ordering of the acyl chains as a function of protein-to-lipid ratio. These results are discussed in a comparative view.
我们通过X射线反射率和来自定向平面双层膜的散射，研究了三种病毒离子通道蛋白的跨膜结构域对脂质双层膜结构的影响。这些蛋白对脂质双层膜结构参数表现出相似的影响：脂质双层膜疏水核心增加、垂直密度分布振幅降低，以及酰基链有序性随蛋白质与脂质比例的变化而发生系统性改变。我们从比较的角度对这些结果进行了讨论。
