Shin Aesun, Li Honglan, Shu Xiao-Ou, Yang Gong, Gao Yu-Tang, Zheng Wei
Department of Medicine, Center for Health Services Research and Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232-2587, USA.
Int J Cancer. 2006 Dec 15;119(12):2938-42. doi: 10.1002/ijc.22196.
We evaluated the associations of dietary intake of calcium, fiber and vitamins with colorectal cancer risk in a population-based prospective cohort study conducted among Chinese women in Shanghai. Subjects were recruited in urban Shanghai from March 1997 to May 2000. All subjects were interviewed in-person to obtain information on demographic and lifestyle factors and anthropometric measurement was conducted. Usual dietary intake, using a validated food frequency questionnaire was assessed at the baseline survey. After following a total of 73,314 women for a median of 5.74 years, 283 incident colorectal cancer cases were recorded. Excluding the first 2 years of follow-up, a high intake of calcium was associated with a decreased risk of colorectal cancer. Comparing the highest quintile of nutrients intake to the lowest, the adjusted relative risk for colorectal cancer was 0.6 (p value for trend = 0.023) for calcium. No apparent associations were found for fiber, total vitamin A, carotene, vitamins B1, B2, B3, C and E with colorectal cancer risk. Our results suggest that calcium may be protective against colorectal cancer development even at a lower consumption level compared to Western populations.
在一项针对上海中国女性开展的基于人群的前瞻性队列研究中，我们评估了钙、纤维和维生素的膳食摄入量与结直肠癌风险之间的关联。研究对象于1997年3月至2000年5月在上海市区招募。所有研究对象均接受了面对面访谈，以获取人口统计学和生活方式因素方面的信息，并进行了人体测量。在基线调查时，使用经过验证的食物频率问卷评估了通常的膳食摄入量。在对总共73314名女性进行了中位时间为5.74年的随访后，记录了283例结直肠癌新发病例。排除随访的前2年，高钙摄入量与结直肠癌风险降低相关。将营养素摄入量的最高五分位数与最低五分位数进行比较，钙摄入量与结直肠癌的校正相对风险为0.6（趋势p值=0.023）。未发现纤维、总维生素A、胡萝卜素、维生素B1、B2、B3、C和E与结直肠癌风险有明显关联。我们的结果表明，即使与西方人群相比，较低的钙消费水平也可能对结直肠癌的发生具有保护作用。
