Han Xiaoyong, Zhao Rangyin, Zhang Guangming, Jiao Yajun, Wang Yongfeng, Wang Da, Cai Hui
Graduate School, Ning Xia Medical University, Yinchuan, China.
General Surgery Clinical Medical Center, Gansu Provincial Hospital, Lanzhou, China.
Front Nutr. 2022 Jun 30;9:918777. doi: 10.3389/fnut.2022.918777. eCollection 2022.
Colorectal cancer (CRC) risk is linked to serum and dietary retinol and carotenoids, according to clinical and epidemiological research. However, the findings are not consistent. As a result, we did this meta-analysis to determine the link between them.
From 2000 through 2022, the PubMed, Web of Science, and Embase databases, as well as pertinent article references, were searched and filtered based on inclusion and exclusion criteria and literature quality ratings. High and low intake were used as controls, and OR (odds ratio) or RR (relative risk) and 95% confidence interval were extracted. The extracted data were plotted and analyzed using Stata12.0 software.
A total of 22 relevant studies were included, including 18 studies related to diet and 4 studies related to serum. For high and low intake or concentration controls, the pooled OR was as follows: β-carotene (OR = 0.89, 95% CI: 0.78-1.03), α-carotene (OR = 0.87, 95% CI: 0.72-1.03), lycopene (OR = 0.93, 95% CI: 0.81-1.07), lutein/zeaxanthin (OR = 0.96, 95% CI: 0.87-1.07), β-cryptoxanthin (OR = 0.70, 95% CI: 0.48-1.01), total carotenoids (OR = 0.97, 95% CI: 0.81-1.15), retinol (OR = 0.99, 95% CI: 0.89-1.10), serum carotenoids (OR = 0.73, 95% CI: 0.58-0.93), serum retinol (OR = 0.62, 95% CI: 0.26-1.49). Subgroup analysis was performed according to tumor type, study type and sex.
Total carotenoid intake and Lutein/Zeaxanthin intake were not associated with CRC risk. High β-carotene, α-carotene, lycopene, and β-cryptoxanthin all tended to reduce CRC risk. Serum carotenoid concentrations were significantly inversely associated with CRC risk.
根据临床和流行病学研究，结直肠癌（CRC）风险与血清及膳食中的视黄醇和类胡萝卜素有关。然而，研究结果并不一致。因此，我们进行了这项荟萃分析以确定它们之间的联系。
检索2000年至2022年期间的PubMed、Web of Science和Embase数据库以及相关文章参考文献，并根据纳入和排除标准及文献质量评级进行筛选。以高摄入量和低摄入量作为对照，提取比值比（OR）或相对风险（RR）及95%置信区间。使用Stata12.0软件对提取的数据进行绘图和分析。
共纳入22项相关研究，其中18项与饮食有关，4项与血清有关。对于高摄入量和低摄入量或浓度对照，汇总后的OR如下：β-胡萝卜素（OR = 0.89，95% CI：0.78 - 1.03），α-胡萝卜素（OR = 0.87，95% CI：0.72 - 1.03），番茄红素（OR = 0.93，95% CI：0.81 - 1.07），叶黄素/玉米黄质（OR = 0.96，95% CI：0.87 - 1.07），β-隐黄质（OR = 0.70，95% CI：0.48 - 1.01），总类胡萝卜素（OR = 0.97，95% CI：0.81 - 1.15），视黄醇（OR = 0.99，95% CI：0.89 - 1.10），血清类胡萝卜素（OR = 0.73，95% CI：0.58 - 0.93），血清视黄醇（OR = 0.62，95% CI：0.26 - 1.49）。根据肿瘤类型、研究类型和性别进行亚组分析。
总类胡萝卜素摄入量和叶黄素/玉米黄质摄入量与结直肠癌风险无关。高剂量的β-胡萝卜素、α-胡萝卜素、番茄红素和β-隐黄质均倾向于降低结直肠癌风险。血清类胡萝卜素浓度与结直肠癌风险呈显著负相关。
