Servicio de Medicina Interna, Hospital Universitario de Cabueñes, Gijón, Asturias, Spain.
Department of Pharmacy, Complejo Asistencial Universitario de León, León, Spain.
Cancer Causes Control. 2022 Feb;33(2):167-182. doi: 10.1007/s10552-021-01512-3. Epub 2021 Oct 27.
The aim of this study is to analyze the current evidence about the relationships between calcium/vitamin D and CRC based on case-control studies according to sex, tumor location and continental region to complement the information obtained in meta-analyses of other designs.
The articles were located in three databases (PUBMED, EMBASE and SCOPUS), they should be written in English language, with a case and control design and published between 1 January 1970 and 31 October 2019.
There were 37 selected studies, 32 for intake of calcium, that involved 24,353 CRC cases and 30,650 controls, and 23 for that of VIT D, with a total of 19,076 cases and 36.746 controls included. For dietary calcium intake, the overall OR was 0.94 (95% CI 0.92-0.97), suggesting a reducing effect with a 6% decrease in CRC risk for every 300 mg of calcium ingested daily. Regarding vitamin D intake a global OR of 0.96 (95% CI 0.93-0.98) was observed, what means a 4% decrease in the risk of CRC per 100 IU/day of vitamin D.
Higher dietary intakes of calcium and vitamin D are associated to a decreased risk of CRC.
本研究旨在根据性别、肿瘤位置和大陆区域，对基于病例对照研究的钙/维生素 D 与 CRC 之间的关系进行分析，以补充其他设计类型的荟萃分析所获得的信息。
在三个数据库（PUBMED、EMBASE 和 SCOPUS）中查找文章，这些文章应使用英文撰写，采用病例对照设计，并于 1970 年 1 月 1 日至 2019 年 10 月 31 日期间发表。
共选择了 37 项研究，其中 32 项是关于钙摄入量的，共涉及 24353 例 CRC 病例和 30650 例对照，23 项是关于维生素 D 摄入量的，共涉及 19076 例病例和 36746 例对照。对于膳食钙摄入量，总体 OR 为 0.94（95%CI 0.92-0.97），这表明每天摄入 300mg 钙可降低 6%的 CRC 风险。关于维生素 D 摄入量，观察到全球 OR 为 0.96（95%CI 0.93-0.98），这意味着每天摄入 100IU 维生素 D 可降低 4%的 CRC 风险。
较高的膳食钙和维生素 D 摄入量与 CRC 风险降低有关。
