Nilsen Tom I L, Romundstad Pål R, Vatten Lars J
Department of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology, NO-7489 Trondheim, Norway.
Int J Cancer. 2006 Dec 15;119(12):2943-7. doi: 10.1002/ijc.22184.
Physical activity has been studied in relation to prostate cancer risk, but the findings have been inconclusive. We prospectively examined the association between self-reported recreational physical activity and overall risk of prostate cancer, risk of advanced disease and risk of prostate cancer death in a cohort of 29,110 Norwegian men. Incident prostate cancers were obtained from the Norwegian Cancer Registry, and prostate cancer deaths were obtained from the national Cause of Death Registry. During 17 years of follow-up, 957 incident cases were identified, 266 of them were advanced (i.e. metastases at diagnosis) and 354 of the incident cases died from prostate cancer. In multivariable analysis, frequency and duration of exercise were inversely associated with the risk of advanced prostate cancer (p for trend = 0.04 and 0.02). We computed a summary score that combined frequency, duration and intensity of exercise, and this score showed inverse associations with advanced prostate cancer risk and mortality (p for trend = 0.02 and 0.07). Compared to men who reported no activity, the relative risks (95% confidence intervals) among men in the highest category of physical exercise was 0.64 (0.43-0.95) for advanced prostate cancer and 0.67 (0.48-0.94) for prostate cancer death. We found no association between physical activity and overall risk of prostate cancer. We conclude that recreational physical exercise is associated with reduced risk of advanced prostate cancer and prostate cancer death.
已有研究探讨了身体活动与前列腺癌风险之间的关系，但研究结果尚无定论。我们前瞻性地研究了29110名挪威男性队列中自我报告的休闲身体活动与前列腺癌总体风险、晚期疾病风险和前列腺癌死亡风险之间的关联。新发前列腺癌病例来自挪威癌症登记处，前列腺癌死亡病例来自国家死亡原因登记处。在17年的随访期间，共确定了957例新发病例，其中266例为晚期（即诊断时已有转移），354例新发病例死于前列腺癌。在多变量分析中，运动频率和持续时间与晚期前列腺癌风险呈负相关（趋势p值分别为0.04和0.02）。我们计算了一个综合运动频率、持续时间和强度的汇总评分，该评分与晚期前列腺癌风险和死亡率呈负相关（趋势p值分别为0.02和0.07）。与报告无身体活动的男性相比，体育锻炼最高类别男性中晚期前列腺癌的相对风险（95%置信区间）为0.64（0.43 - 0.95），前列腺癌死亡的相对风险为0.67（0.48 - 0.94）。我们未发现身体活动与前列腺癌总体风险之间存在关联。我们得出结论，休闲体育锻炼与降低晚期前列腺癌风险和前列腺癌死亡风险相关。
