Forrester Mathias B, Merz Ruth D
Hawaii Birth Defects Program, Honolulu, Hawaii 96817-5157, USA.
Birth Defects Res A Clin Mol Teratol. 2006 Nov;76(11):778-80. doi: 10.1002/bdra.20257.
Information on the utilization of prenatal ultrasound (US), amniocentesis (AC), and chorionic villus sampling (CVS) in pregnancies affected by birth defects in the United States is limited. The intent of this study was to report on the utilization of these procedures in Hawaii.
Cases were all infants and fetuses of any pregnancy outcome with birth defects, included in a Hawaii birth defects registry, and delivered during 1986-2002. The rates of prenatal US, AC/CVS, and prenatal diagnosis were calculated.
Prenatal US was performed in 76% of the cases and AC/CVS in 14% of the cases. Prenatal diagnosis of a birth defect was made in 16% of the cases. The prenatal US, AC/CVS, and prenatal diagnosis rates in 1998-2002 were 1.5, 1.5, and 1.7 times the rates in 1986-1991, respectively. Among all birth defects, the AC/CVS rate for women aged <35 years was 7% and for women aged > or =35 years was 48%. Among chromosomal abnormalities, the AC/CVS rate for women aged <35 years was 36% and for women aged > or =35 years was 66%.
Only a fraction of the Hawaii birth defects cases was prenatally diagnosed. The rates for prenatal US, AC/CVS, and prenatal diagnosis among pregnancies affected by birth defects were higher in 1998-2002 than in 1986-1991. AC/CVS rates were lower for maternal age <35 years.
在美国，关于出生缺陷相关妊娠中产前超声（US）、羊膜穿刺术（AC）和绒毛取样（CVS）使用情况的信息有限。本研究旨在报告这些检查在夏威夷的使用情况。
病例为1986 - 2002年期间在夏威夷出生缺陷登记处登记的、有任何妊娠结局且患有出生缺陷的所有婴儿和胎儿。计算产前超声、AC/CVS和产前诊断的比率。
76%的病例进行了产前超声检查，14%的病例进行了AC/CVS检查。16%的病例进行了出生缺陷的产前诊断。1998 - 2002年的产前超声、AC/CVS和产前诊断比率分别是1986 - 1991年的1.5倍、1.5倍和1.7倍。在所有出生缺陷中，年龄<35岁女性的AC/CVS比率为7%，年龄≥35岁女性的比率为48%。在染色体异常中，年龄<35岁女性的AC/CVS比率为36%，年龄≥35岁女性的比率为66%。
夏威夷出生缺陷病例中只有一小部分进行了产前诊断。1998 - 2002年出生缺陷相关妊娠的产前超声、AC/CVS和产前诊断比率高于1986 - 1991年。年龄<35岁产妇的AC/CVS比率较低。
