Plech Agata R, Herba Ewa, Pojda-Wilczek Dorota, Makowiecka-Obidzińska Katarzyna, Pojda Stefan M, Plech Andrzej
Katedry i Oddziału Klinicznego Okulistyki w Bytomiu Slaskiej Akademii Medycznej w Katowicach.
Klin Oczna. 2006;108(4-6):159-62.
The topic of this paper is to define the influence of stimulation dopaminergic D1 i D2 receptors in lateral geniculate body by flash visual evoked potentials (FVEP).
Wistar rats were examined. There were stereotaxically implanted with guide caniula into the lateral geniculate body to inject substances and with VEPs electrodes on the skull and on the surface of visual cortex. VEPs curve before and after injection into the lateral geniculate body: 0.9% NaCl, agonists of dopamine receptors D1 - SKF 38393, and D2 Quinpirole and also the same agonist after antagonists D1 - SCH 23390, i D2 Sulpiride were analyzed.
Stimulating receptors D1 in the lateral geniculate body cause amplitude increase and shortness of latency. Quinpirole, agonist of D2 receptor do not significant change FVEPs curve.
Stimulation of D1 receptors in the lateral geniculate body can improve visual transmission throught it and response in the occipital cortex.
本文主题是通过闪光视觉诱发电位（FVEP）来确定刺激外侧膝状体中多巴胺能D1和D2受体的影响。
对Wistar大鼠进行检查。通过立体定向将引导套管植入外侧膝状体以注射物质，并在颅骨和视觉皮层表面放置视觉诱发电位电极。分析向外侧膝状体注射以下物质前后的视觉诱发电位曲线：0.9%氯化钠、多巴胺受体D1激动剂SKF 38393、D2激动剂喹吡罗，以及在D1拮抗剂SCH 23390和D2拮抗剂舒必利之后注射相同的激动剂。
刺激外侧膝状体中的D1受体可导致振幅增加和潜伏期缩短。D2受体激动剂喹吡罗对视觉诱发电位曲线无显著影响。
刺激外侧膝状体中的D1受体可改善通过它的视觉传导以及枕叶皮层的反应。
