Goertz S R, Ali M M, Parker G A
Department of Radiation Oncology, Medical College of Virginia, Richmond.
Clin Oncol (R Coll Radiol). 1990 Jan;2(1):22-6. doi: 10.1016/s0936-6555(05)80214-6.
A retrospective review of patients with pancreatic carcinoma treated from 1983 to 1986 was performed. Group 1 comprise 11 patients judged surgically unresectable who were implanted with iodine-125 followed by external beam therapy post-operatively (Implant + XRT). Eight patients received external beam therapy alone (XRT) Group 2, and 23 patients underwent radical surgical resection (group 3). Median survival was 8 months in the implant + XRT group; 5 months in the XRT alone group and 7.5 months in the surgical group. Locoregional control was achieved in 8/11 (73%), 2/8 (25%), and 11/23 (48%) of these groups respectively. Pain was the most common presenting symptom, 38/42 (90%). Complete, lasting palliation was achieved in 8/10 (80%) of group one, 2/8 (25%) of group two, and 13/20 (65%) of group three patients. Despite surgical unresectability implant + XRT appears to offer similar results to radical surgery. The data are presented with respect to the implant technique, disappearance of the tumour on CT scan and patterns of failure.
对1983年至1986年期间接受治疗的胰腺癌患者进行了回顾性研究。第一组包括11名经判断无法进行手术切除的患者，他们接受了碘-125植入，随后在术后接受外照射治疗（植入+外照射）。第二组8名患者仅接受外照射治疗（外照射），第三组23名患者接受了根治性手术切除。植入+外照射组的中位生存期为8个月；单纯外照射组为5个月，手术组为7.5个月。这些组中分别有8/11（73%）、2/8（25%）和11/23（48%）实现了局部控制。疼痛是最常见的症状，占38/42（90%）。第一组10名患者中有8/10（80%）、第二组8名患者中有2/8（25%）、第三组20名患者中有13/20（65%）实现了完全、持久的症状缓解。尽管无法进行手术切除，但植入+外照射似乎能提供与根治性手术相似的结果。文中还介绍了植入技术、CT扫描上肿瘤的消失情况以及失败模式的数据。
