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固态槲皮素不同样品的表征:多晶型现象出现的迹象

Characterization of different samples of quercetin in solid-state: indication of polymorphism occurrence.

作者信息

Borghetti G S, Costa I M, Petrovick P R, Pereira V P, Bassani V L

机构信息

Programa de Pós-Graduação em Ciências Farmacêuticas, Departamento de Controle e Produção de Medicamentos, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Allegre, Brasil.

出版信息

Pharmazie. 2006 Sep;61(9):802-4.

PMID:17020162
Abstract

The present work was designed to compare four commercial samples of quercetin, three of them presenting pharmaceutical grade (QPGa, QPGb and QPGc) and the other one pro-analysi grade (QPA) by means of different techniques. Physical and chromatographic characterization of these samples shows different properties following its origin, especially a clear evidence of polymorphism occurrence.

摘要

本研究旨在通过不同技术比较四种槲皮素商业样品,其中三种为药用级(QPGa、QPGb和QPGc),另一种为分析纯级(QPA)。这些样品的物理和色谱表征显示出其来源不同的特性,特别是明显存在多态性的证据。

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Quercetin/beta-cyclodextrin solid complexes prepared in aqueous solution followed by spray-drying or by physical mixture.
槲皮素/β-环糊精固体复合物通过在水溶液中制备,然后喷雾干燥或通过物理混合得到。
AAPS PharmSciTech. 2009;10(1):235-42. doi: 10.1208/s12249-009-9196-3. Epub 2009 Mar 12.