Mseddi M, Marrekchi S, Bouassida S, Meziou Th, Boudaya S, Turki H, Zahaf A
Service de Dermatologie, CHU H. Chaker, Sfax, Tunisie.
Rev Med Liege. 2006 Jul-Aug;61(7-8):589-92.
Necrobiosis lipoidica is a rare degenerative disease mostly seen on the legs. The association to diabetes mellitus is usual. We report three patients with necrobiosis lipoidica located on the extremities, 2 of them were already treated for diabetes. Necrobiosis lipoidica has distinctive clinical and histological appearances. The lesions appear as well circumscribed, erythematous plaques, with a depressed centre. Some of these lesions may progress to ulcers. The legs are commonly involved. Angiopathy leading to thrombosis of the cutaneous vessels has been implicated in its pathogeny. There is no specific therapy for this disease Topical and/or intralesional corticosteroids are the most widely used treatment.
类脂质渐进性坏死是一种罕见的退行性疾病，多见于腿部。与糖尿病相关很常见。我们报告了3例肢体患有类脂质渐进性坏死的患者，其中2例已接受糖尿病治疗。类脂质渐进性坏死有独特的临床和组织学表现。病变表现为边界清楚的红斑性斑块，中央凹陷。其中一些病变可能发展为溃疡。腿部常受累。导致皮肤血管血栓形成的血管病变与其发病机制有关。这种疾病没有特效疗法。局部和/或病损内注射皮质类固醇是最广泛使用的治疗方法。
