Tan Jason Samuel, Ciufolini Marco A
Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada.
Org Lett. 2006 Oct 12;8(21):4771-4. doi: 10.1021/ol0617291.
[reaction: see text] We describe a straightforward synthesis of topopyrones B and D, which are potent and selective inhibitors of topoisomerase I. The chemistry should be suitable for additional structure-activity relationship (SAR) work.
