Thorner Anna R, Vogels Ronald, Kaspers Jorn, Weverling Gerrit J, Holterman Lennart, Lemckert Angelique A C, Dilraj Athmanundh, McNally Lisa M, Jeena Prakash M, Jepsen Soren, Abbink Peter, Nanda Anjali, Swanson Patricia E, Bates Andrew T, O'Brien Kara L, Havenga Menzo J E, Goudsmit Jaap, Barouch Dan H
Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Research East, Room 213, 330 Brookline Avenue, Boston, MA 02215, USA.
J Clin Microbiol. 2006 Oct;44(10):3781-3. doi: 10.1128/JCM.01249-06.
We assessed neutralizing antibody titers to adenovirus serotype 5 (Ad5) and six rare adenovirus serotypes, serotypes 11, 35, 50, 26, 48, and 49, in pediatric populations in sub-Saharan Africa. We observed a clear age dependence of Ad5-specific neutralizing antibody titers. These data will help to guide the development of Ad vector-based vaccines for human immunodeficiency virus type 1 and other pathogens.
我们评估了撒哈拉以南非洲地区儿童群体中针对5型腺病毒(Ad5)以及6种罕见腺病毒血清型(11型、35型、50型、26型、48型和49型)的中和抗体滴度。我们观察到Ad5特异性中和抗体滴度存在明显的年龄依赖性。这些数据将有助于指导针对1型人类免疫缺陷病毒和其他病原体的基于腺病毒载体的疫苗的开发。