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本文引用的文献

1
Age dependence of adenovirus-specific neutralizing antibody titers in individuals from sub-Saharan Africa.撒哈拉以南非洲地区个体中腺病毒特异性中和抗体滴度的年龄依赖性
J Clin Microbiol. 2006 Oct;44(10):3781-3. doi: 10.1128/JCM.01249-06.
2
An adenovirus-based HIV subtype B prime/boost vaccine regimen elicits antibodies mediating broad antibody-dependent cellular cytotoxicity against non-subtype B HIV strains.一种基于腺病毒的HIV B亚型初免/加强疫苗方案可引发介导针对非B亚型HIV毒株的广泛抗体依赖性细胞毒性的抗体。
J Acquir Immune Defic Syndr. 2006 Nov 1;43(3):270-7. doi: 10.1097/01.qai.0000230318.40170.60.
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Intracoronary delivery of an adenovirus encoding fibroblast growth factor-4 in myocardial ischemia: effect of serum antibodies and previous exposure to adenovirus.腺病毒介导的成纤维细胞生长因子-4基因冠状动脉内给药治疗心肌缺血：血清抗体及既往腺病毒暴露的影响
Hum Gene Ther. 2006 Feb;17(2):230-8. doi: 10.1089/hum.2006.17.230.
4
Broad cellular immunity with robust memory responses to simian immunodeficiency virus following serial vaccination with adenovirus 5- and 35-based vectors.用基于腺病毒5型和35型载体进行系列疫苗接种后，对猿猴免疫缺陷病毒产生具有强大记忆反应的广泛细胞免疫。
J Gen Virol. 2006 Jan;87(Pt 1):139-149. doi: 10.1099/vir.0.81445-0.
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Detection of antibodies against adenovirus protein IX, fiber, and hexon in human sera by immunoblot assay.通过免疫印迹法检测人血清中针对腺病毒蛋白IX、纤维蛋白和六邻体的抗体。
J Clin Microbiol. 2005 Sep;43(9):4426-33. doi: 10.1128/JCM.43.9.4426-4433.2005.
6
Immunization with recombinant adenovirus synthesizing the secretory form of Japanese encephalitis virus envelope protein protects adenovirus-exposed mice against lethal encephalitis.用合成日本脑炎病毒包膜蛋白分泌形式的重组腺病毒进行免疫接种，可保护接触过腺病毒的小鼠免受致命性脑炎的侵害。
Microbes Infect. 2006 Jan;8(1):92-104. doi: 10.1016/j.micinf.2005.05.023. Epub 2005 Aug 9.
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Tumor cell targeted gene delivery by adenovirus 5 vectors carrying knobless fibers with antibody-binding domains.携带具有抗体结合结构域的无柄纤维的腺病毒5载体介导的肿瘤细胞靶向基因递送
Gene Ther. 2005 Feb;12(3):211-24. doi: 10.1038/sj.gt.3302408.
8
Gene transduction and cell entry pathway of fiber-modified adenovirus type 5 vectors carrying novel endocytic peptide ligands selected on human tracheal glandular cells.携带在人气管腺细胞上筛选出的新型内吞肽配体的纤维修饰5型腺病毒载体的基因转导和细胞进入途径。
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An adenovirus vector with a chimeric fiber derived from canine adenovirus type 2 displays novel tropism.一种带有源自犬2型腺病毒的嵌合纤维的腺病毒载体表现出新型嗜性。
Virology. 2004 Jun 20;324(1):103-16. doi: 10.1016/j.virol.2004.03.028.
10
Adenovirus types 5 and 35 seroprevalence in AIDS risk groups supports type 35 as a vaccine vector.艾滋病风险群体中5型和35型腺病毒血清流行率表明35型可作为疫苗载体。
AIDS. 2004 May 21;18(8):1213-6. doi: 10.1097/00002030-200405210-00019.

印度儿童中针对5型腺病毒的中和抗体血清流行率：对基于重组腺病毒的疫苗的影响。

Seroprevalence of neutralizing antibodies to adenovirus type 5 among children in India: implications for recombinant adenovirus-based vaccines.

作者信息

Appaiahgari Mohan Babu, Pandey Ravindra Mohan, Vrati Sudhanshu

机构信息

National Institute of Immunology, Aruna saf Ali Marg, JNU Complex, New Delhi 110067, India.

出版信息

Clin Vaccine Immunol. 2007 Aug;14(8):1053-5. doi: 10.1128/CVI.00173-07. Epub 2007 Jun 27.

DOI:10.1128/CVI.00173-07
PMID:17596429
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2044479/
Abstract

We determined the levels of adenovirus 5 (Ad5) neutralizing antibodies in children in India less than 2 years of age. The results clearly show an age-dependent increase in Ad5-specific immunity, with 7- to 12-month-old children having the lowest levels of Ad5 immunity. This opens up the scope for the use of recombinant Ad5-based vaccines in this age group.

摘要

我们测定了印度2岁以下儿童体内腺病毒5型（Ad5）中和抗体的水平。结果清楚地显示，Ad5特异性免疫力随年龄增长而增加，7至12个月大的儿童Ad5免疫力水平最低。这为在该年龄组使用基于重组Ad5的疫苗开辟了空间。