Sayedahmed Ekramy E, Elkashif Ahmed, Alhashimi Marwa, Sambhara Suryaprakash, Mittal Suresh K
Department of Comparative Pathobiology, Purdue Institute for Immunology, Inflammation and Infectious Disease, Purdue University Center for Cancer Research, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA.
Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
Vaccines (Basel). 2020 Oct 1;8(4):574. doi: 10.3390/vaccines8040574.
Ever since the discovery of vaccines, many deadly diseases have been contained worldwide, ultimately culminating in the eradication of smallpox and polio, which represented significant medical achievements in human health. However, this does not account for the threat influenza poses on public health. The currently licensed seasonal influenza vaccines primarily confer excellent strain-specific protection. In addition to the seasonal influenza viruses, the emergence and spread of avian influenza pandemic viruses such as H5N1, H7N9, H7N7, and H9N2 to humans have highlighted the urgent need to adopt a new global preparedness for an influenza pandemic. It is vital to explore new strategies for the development of effective vaccines for pandemic and seasonal influenza viruses. The new vaccine approaches should provide durable and broad protection with the capability of large-scale vaccine production within a short time. The adenoviral (Ad) vector-based vaccine platform offers a robust egg-independent production system for manufacturing large numbers of influenza vaccines inexpensively in a short timeframe. In this review, we discuss the progress in the development of Ad vector-based influenza vaccines and their potential in designing a universal influenza vaccine.
自疫苗被发现以来，全球范围内许多致命疾病已得到控制，最终实现了天花和脊髓灰质炎的根除，这是人类健康领域的重大医学成就。然而，这并未消除流感对公众健康构成的威胁。目前已获许可的季节性流感疫苗主要提供针对特定毒株的出色保护。除了季节性流感病毒外，H5N1、H7N9、H7N7和H9N2等禽流感大流行病毒在人类中的出现和传播凸显了采取新的全球流感大流行防范措施的紧迫性。探索针对大流行和季节性流感病毒开发有效疫苗的新策略至关重要。新的疫苗方法应提供持久而广泛的保护，并具备在短时间内大规模生产疫苗的能力。基于腺病毒（Ad）载体的疫苗平台提供了一个强大的不依赖鸡蛋的生产系统，能够在短时间内以低成本生产大量流感疫苗。在本综述中，我们讨论了基于Ad载体的流感疫苗的研发进展及其在设计通用流感疫苗方面的潜力。
