Akbari Milan R, Sonawane Snehal
Pathology and Laboratory Medicine, UI Health/University of Illinois at Chicago, Chicago, USA.
Cureus. 2024 Oct 29;16(10):e72666. doi: 10.7759/cureus.72666. eCollection 2024 Oct.
Reactive spindle cell nodules (RSCNs) that occur after fine needle aspiration (FNA) are commonly documented in the literature. They are benign proliferation of spindle cells with some mitotic figures and nuclear pleomorphism that arise after tissue injuries like FNA. These lesions are non-capsulated and surrounded by parenchyma of organ tissue. Although RSCNs after FNA can occur in various organs of the body, there is a lack of well-established studies describing their presence in the pancreas. We present a case of a 74-year-old female treated with pancreatectomy for intraductal papillary mucinous neoplasm (IPMN), and RSCNs were found incidentally during post-surgery microscopic evaluation. This lesion showed similar characteristic microscopic features of the RSCNs found at different anatomical sites. To the best of our knowledge, this may be the first case of RSCNs after FNA into the pancreatic. This case expands the diagnostic framework of pancreatic spindle cell tumors.
细针穿刺活检（FNA）后出现的反应性梭形细胞结节（RSCNs）在文献中已有广泛记载。它们是梭形细胞的良性增殖，伴有一些有丝分裂象和核异型性，在诸如FNA等组织损伤后出现。这些病变无包膜，被器官组织实质所包绕。尽管FNA后的RSCNs可发生于身体的各个器官，但缺乏关于其在胰腺中存在情况的确切研究。我们报告一例74岁女性，因导管内乳头状黏液性肿瘤（IPMN）接受了胰腺切除术，术后显微镜检查时偶然发现了RSCNs。该病变显示出与在不同解剖部位发现的RSCNs相似的典型显微镜特征。据我们所知，这可能是首例FNA穿刺胰腺后出现RSCNs的病例。该病例扩展了胰腺梭形细胞瘤的诊断范围。
